{"id":"W4388589111","doi":"10.1093/neuonc/noad179.0181","title":"CSIG-25. OVERCOMING RESISTANCE TO THERAPIES TARGETING THE MAPK PATHWAY IN GLIOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"","keywords":"MAPK/ERK pathway; Cancer research; Psychological repression; Repressor; Transcription factor; Receptor tyrosine kinase; Context (archaeology); Signal transduction; Carcinogenesis; Kinase; Biology; Cell biology; Cancer; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001894336,0.0003108481,0.0006430421,0.0005605379,0.000208349,0.0003918989,0.0004361304,0.0003127968,0.001519084],"category_scores_gemma":[0.0001080317,0.0001338129,0.0003091334,0.0004069936,0.000264901,0.0001352404,0.0002529496,0.0007118603,0.0005178297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006821667,"about_ca_system_score_gemma":0.0007041747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00246839,"about_ca_topic_score_gemma":0.005686435,"domain_scores_codex":[0.9999037,0.00001050235,0.000005907056,0.00001320733,0.00002038344,0.00004625075],"domain_scores_gemma":[0.9999493,0.000003937462,0.00000594259,0.000006433388,0.000006300916,0.00002797459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004859658,0.002331136,0.004321155,0.0007515434,0.0002413769,0.001440169,0.0001373975,0.003391909,0.7681534,0.001602409,0.007381817,0.205388],"study_design_scores_gemma":[0.002310902,0.03242942,0.05689409,0.0001789425,0.0005493644,0.004425853,0.0002662508,0.008795129,0.8199856,0.001018892,0.07303972,0.0001058713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835565,0.009090837,0.0006049165,0.0004552919,0.0001158583,0.0002159943,0.0006572438,0.0002931955,0.005010195],"genre_scores_gemma":[0.9934464,0.002635366,0.0007306334,0.0001771173,0.00001362553,0.00006649321,0.001041734,0.00001761955,0.001870982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00246839,"threshold_uncertainty_score":0.005081832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01344509706225625,"score_gpt":0.2824663745543413,"score_spread":0.269021277492085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}