{"id":"W4388589166","doi":"10.1093/neuonc/noad179.0138","title":"STEM-12. TARGETING GLIOBLASTOMA WITH A BRAIN PENETRANT DRUG THAT IMPAIRS BRAIN TUMOUR STEM CELLS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Stem cell; Cancer research; Biology; DNA repair; Neural stem cell; Cell cycle; Cancer stem cell; Notch signaling pathway; Transcriptome; Cell; Signal transduction; Gene; Cell biology; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043642,0.000420856,0.0002887149,0.0003651132,0.0001330799,0.0002396686,0.0002030969,0.0003288795,0.001465171],"category_scores_gemma":[0.00006023743,0.000112487,0.0002076454,0.00021825,0.0001990035,0.0001320955,0.0001464398,0.0004617914,0.0003339839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002421084,"about_ca_system_score_gemma":0.0002768715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008669172,"about_ca_topic_score_gemma":0.001503759,"domain_scores_codex":[0.9999009,0.00001116783,0.00001381188,0.00002120051,0.00003103977,0.00002183954],"domain_scores_gemma":[0.9999448,0.000005844689,0.00002038664,0.000006688116,0.00000670614,0.00001560358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002012333,0.0001368021,0.0001696204,0.00005781074,0.000009213867,0.00006531776,0.00001114847,0.0001351876,0.9953884,0.0002081001,0.0001282888,0.003488737],"study_design_scores_gemma":[0.00003786482,0.0009065678,0.001539412,0.000005398266,0.00001789266,0.0001941929,0.00001224617,0.0005294897,0.9936383,0.0000483644,0.003066815,0.000003297471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920589,0.001461511,0.002387069,0.0001808301,0.00006746786,0.0001131822,0.001065779,0.0002022565,0.002463073],"genre_scores_gemma":[0.9938916,0.0009563435,0.00158096,0.00007516881,0.00000854854,0.00006322054,0.0008437429,0.0000162872,0.002564173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001465171,"threshold_uncertainty_score":0.004901469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01419232894902264,"score_gpt":0.256676528824476,"score_spread":0.2424841998754534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}