{"id":"W4388589215","doi":"10.1093/neuonc/noad179.0267","title":"CTIM-27. PERIPHERAL BIOMARKER ANALYSIS OF T CELL-MEDIATED COLLAGEN REMODELING CORRELATES WITH TUMOR RESPONSES IN A PHASE IIA TRIAL OF VACCINE IMMUNOTHERAPEUTIC CANDIDATE (VBI-1901)","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Variation Biotechnologies (Canada)","funders":"","keywords":"Medicine; CD8; Biomarker; Immune system; Antigen; T cell; Granzyme B; Immunotherapy; Immunology; ELISPOT; Nivolumab; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007216354,0.0004373638,0.0005729164,0.0001589921,0.0001669115,0.00047099,0.0002177999,0.0003874763,0.001176873],"category_scores_gemma":[0.0003981011,0.0002043825,0.0002380183,0.0001332108,0.0002717548,0.0002070065,0.0001237122,0.0009758794,0.0003861407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003936512,"about_ca_system_score_gemma":0.0004086667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003337271,"about_ca_topic_score_gemma":0.0006012279,"domain_scores_codex":[0.9997988,0.00006744819,0.00001113362,0.00004031539,0.00002407769,0.00005821977],"domain_scores_gemma":[0.9997461,0.00003804166,0.00005333992,0.00002151706,0.00002074255,0.0001201176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3262164,0.02365375,0.06844889,0.0004441732,0.0005162947,0.0003899041,0.000276265,0.002891676,0.4660619,0.0002695657,0.004262355,0.1065687],"study_design_scores_gemma":[0.04617236,0.6313524,0.2164321,0.00005466973,0.0004903682,0.001276388,0.0001195729,0.005259006,0.0920227,0.0001919766,0.006583232,0.00004530629],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983498,0.0004611772,0.0001529544,0.00005363212,0.00002649054,0.0001784366,0.0002338802,0.00001870509,0.0005249824],"genre_scores_gemma":[0.9980433,0.0001223394,0.0002352665,0.00009616659,0.00001781242,0.0001787973,0.0006316124,0.000005052849,0.0006695415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001176873,"threshold_uncertainty_score":0.003937006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0409655345464307,"score_gpt":0.3630091074634387,"score_spread":0.322043572917008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}