{"id":"W4388589461","doi":"10.1093/neuonc/noad179.0319","title":"CTNI-37. CLINICAL ACTIVITY OF RAF INHIBITOR TOVORAFENIB ACCORDING TO PRIOR MAPK INHIBITOR TREATMENT IN THE REGISTRATIONAL PEDIATRIC LOW-GRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Adverse effect; Phases of clinical research; Glioma; Internal medicine; Surgery; Oncology; Cancer research; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001674887,0.001010827,0.001280415,0.0003398094,0.0002479647,0.0009347377,0.000745398,0.000757482,0.003369358],"category_scores_gemma":[0.0009645114,0.0003449788,0.001259789,0.0004106103,0.0004845017,0.0004353277,0.0003205399,0.001485913,0.0007026563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001148015,"about_ca_system_score_gemma":0.001688918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001547871,"about_ca_topic_score_gemma":0.00753223,"domain_scores_codex":[0.9991971,0.000417247,0.00004405979,0.0001181562,0.00008449365,0.0001390315],"domain_scores_gemma":[0.9994167,0.00007678593,0.0001365111,0.00005106088,0.00003018001,0.0002887507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8188851,0.01368917,0.03717883,0.0009600592,0.002566689,0.0002858155,0.0001575581,0.001982776,0.02385205,0.0003285572,0.007002264,0.09311117],"study_design_scores_gemma":[0.4880837,0.3574777,0.1269507,0.0001769173,0.003224266,0.0006790372,0.0001194334,0.002364465,0.007739377,0.0004135875,0.01267588,0.00009507823],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860901,0.006388208,0.0002884126,0.0004135672,0.0001543513,0.0007725355,0.002697541,0.0000662972,0.003129127],"genre_scores_gemma":[0.9900358,0.002081262,0.0005577992,0.0003913132,0.0001355785,0.0006581509,0.003867812,0.00001998953,0.002252361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003369358,"threshold_uncertainty_score":0.01127166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07453843266915541,"score_gpt":0.4059612097002459,"score_spread":0.3314227770310905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}