{"id":"W4388589483","doi":"10.1093/neuonc/noad179.0187","title":"CSIG-31. JAK/STAT PATHWAY CO-OPERATES WITH CIC-FUSIONS TO DRIVE CIC- REARRANGED SARCOMAS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Barrie Urology Group; University of Toronto","funders":"","keywords":"STAT1; Cancer research; STAT protein; Transcription factor; JAK-STAT signaling pathway; Janus kinase 1; Fusion protein; Effector; STAT3; Janus kinase; Signal transduction; STAT4; PIM1; Biology; stat; Gene; Cell biology; Phosphorylation; Receptor tyrosine kinase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479492,0.0002273835,0.0002299768,0.0002302857,0.0001731149,0.0003033095,0.0001895691,0.0002715634,0.002136698],"category_scores_gemma":[0.00009829315,0.0001156332,0.0002066984,0.000232907,0.0002044147,0.00009420894,0.0001537839,0.0005490195,0.0007711282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004188668,"about_ca_system_score_gemma":0.0002953987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105448,"about_ca_topic_score_gemma":0.001992881,"domain_scores_codex":[0.9997973,0.00003094404,0.00002248976,0.00003356299,0.00006436941,0.00005128279],"domain_scores_gemma":[0.9999123,0.00001838779,0.00001802649,0.00001680355,0.000006753942,0.00002772033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001445051,0.0001015316,0.0005096204,0.00003235949,0.000005708593,0.0001025852,0.00001451589,0.0001782817,0.9974227,0.0001479145,0.0002002818,0.001140031],"study_design_scores_gemma":[0.00005511177,0.0004875576,0.005903958,0.000004885941,0.00001570086,0.0006439569,0.00003014521,0.002134625,0.9862635,0.00004129728,0.004415152,0.00000405987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946331,0.0006904081,0.0008209777,0.0001403776,0.00004156477,0.00008184327,0.001236026,0.0001385258,0.002217167],"genre_scores_gemma":[0.9960598,0.0001748229,0.0007923566,0.00004041098,0.000003702963,0.00004153002,0.001212647,0.0000107985,0.00166403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002136698,"threshold_uncertainty_score":0.007148027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708085239291457,"score_gpt":0.2866371462680453,"score_spread":0.2695562938751307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}