{"id":"W4388589496","doi":"10.1093/neuonc/noad179.0306","title":"CTNI-24. CLINICAL ACTIVITY AND SAFETY OF THE RAF INHIBITOR TOVORAFENIB IN PATIENTS WITH OPTIC PATHWAY GLIOMAS IN THE REGISTRATIONAL PEDIATRIC LOW-GRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Adverse effect; Glioma; Internal medicine; Progressive disease; Phases of clinical research; Oncology; Gastroenterology; Surgery; Disease; Cancer research; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007930388,0.0006584727,0.0007597289,0.0002151908,0.0001855064,0.0007294769,0.0004918859,0.0004607372,0.002051306],"category_scores_gemma":[0.0005566293,0.0002065946,0.0007394531,0.0002516288,0.0003069186,0.0003236759,0.0001781678,0.001177678,0.000449493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008519333,"about_ca_system_score_gemma":0.001153532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001297784,"about_ca_topic_score_gemma":0.006397699,"domain_scores_codex":[0.9997017,0.0001457005,0.0000143411,0.00004101108,0.00003762272,0.00005958637],"domain_scores_gemma":[0.999644,0.00003804031,0.00009561419,0.0000208497,0.000024468,0.0001770175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6380365,0.01727729,0.04580101,0.002019388,0.002902463,0.0007821083,0.0003114237,0.004093828,0.07547766,0.0005453276,0.013305,0.199448],"study_design_scores_gemma":[0.4082412,0.4013298,0.1405927,0.0001998099,0.002174919,0.00200798,0.000225386,0.004180952,0.02262432,0.000477064,0.0178405,0.0001053487],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908517,0.004778784,0.0001967246,0.0002844421,0.00007385255,0.000412197,0.001489273,0.00005733646,0.001855628],"genre_scores_gemma":[0.9939787,0.00164207,0.0003676816,0.0001915977,0.00004524981,0.0003082153,0.002090737,0.00001200953,0.001363647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002051306,"threshold_uncertainty_score":0.006862283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03114146325308864,"score_gpt":0.3419781488897158,"score_spread":0.3108366856366272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}