{"id":"W4388589496","doi":"10.1093/neuonc/noad179.0306","title":"CTNI-24. CLINICAL ACTIVITY AND SAFETY OF THE RAF INHIBITOR TOVORAFENIB IN PATIENTS WITH OPTIC PATHWAY GLIOMAS IN THE REGISTRATIONAL PEDIATRIC LOW-GRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Adverse effect; Glioma; Internal medicine; Progressive disease; Phases of clinical research; Oncology; Gastroenterology; Surgery; Disease; Cancer research; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009188057,0.0001874618,0.0005440613,0.0001525783,0.0001039101,0.00000468272,0.0002392989,0.0002150518,0.000007840614],"category_scores_gemma":[0.0006376989,0.00009321016,0.0001150442,0.001149002,0.0003901013,0.00006425272,0.000156562,0.0005957866,0.000002637159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009469223,"about_ca_system_score_gemma":0.0005236129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003150895,"about_ca_topic_score_gemma":0.0003546106,"domain_scores_codex":[0.9969063,0.0014128,0.0006310696,0.0003765977,0.0004235146,0.0002496555],"domain_scores_gemma":[0.9974251,0.001511116,0.0004151708,0.000513153,0.00007725279,0.00005820646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003819422,0.01337646,0.9777349,0.00003987571,0.00007133089,0.0004494838,0.0008430665,0.00001225197,0.001516414,0.0000394496,0.0001021918,0.001995169],"study_design_scores_gemma":[0.02533538,0.008656719,0.9640102,0.00002384319,0.0002058458,0.00004665897,0.0002320421,0.0000421294,0.001103809,0.00004428671,0.0002271211,0.00007194312],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952084,0.00002788819,4.450835e-7,0.001965443,0.0004698649,0.00213508,0.0000294271,0.00001339566,0.000150079],"genre_scores_gemma":[0.9995616,0.00001753905,0.00001977332,0.0001760125,0.0001095752,0.0000764506,0.00001054359,0.00001567833,0.00001283679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02151595,"threshold_uncertainty_score":0.3801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03114146325308864,"score_gpt":0.3419781488897158,"score_spread":0.3108366856366272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}