{"id":"W4388589743","doi":"10.1093/neuonc/noad179.0467","title":"EPCO-02. DNA METHYLATION PROFILING OF BRAIN METASTASIS REVEALS UNDERLING TUMOR RECURRENCE SIGNAL AND ASSOCIATED PATHWAYS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; University Health Network","funders":"","keywords":"DNA methylation; CpG site; Methylation; Epigenetics; Biology; Differentially methylated regions; Cancer research; Metastasis; Molecular biology; Computational biology; Oncology; DNA; Cancer; Medicine; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002914531,0.0002903977,0.0003121842,0.0006843305,0.0002895951,0.0005257539,0.0003679502,0.000361578,0.007005374],"category_scores_gemma":[0.0003400657,0.0001850813,0.0002078175,0.000544337,0.0001597767,0.0001852307,0.0003117824,0.0004217441,0.00212992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003592948,"about_ca_system_score_gemma":0.0005274691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002864864,"about_ca_topic_score_gemma":0.004969219,"domain_scores_codex":[0.9998029,0.00001846538,0.000009633251,0.00007053044,0.00005958639,0.00003889159],"domain_scores_gemma":[0.9998122,0.00002828219,0.0000328736,0.00002184147,0.00005502673,0.0000497016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001649095,0.0001200002,0.0338637,0.0003711962,0.00007004989,0.000283856,0.00006273305,0.0006236155,0.9080722,0.0004939621,0.00587371,0.04851588],"study_design_scores_gemma":[0.0002647873,0.001050208,0.341121,0.00005867761,0.0002103973,0.002737037,0.00009570889,0.009788462,0.6040167,0.0007371697,0.03987772,0.00004215356],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.920875,0.00465984,0.01861656,0.0006184106,0.00009688328,0.0003098189,0.03801303,0.001789524,0.0150209],"genre_scores_gemma":[0.9209343,0.001418921,0.01576985,0.0003487768,0.0000428951,0.0004652161,0.04339727,0.0003260517,0.01729664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007005374,"threshold_uncertainty_score":0.02343529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04339248786605172,"score_gpt":0.3123219602283687,"score_spread":0.268929472362317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}