{"id":"W4388590014","doi":"10.1093/neuonc/noad179.0159","title":"CSIG-03. SHH PATHWAY ACTIVATION IN DEDIFFERENTIATION DURING TUMOUR PROGRESSION IN MPNST","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; McMaster University","funders":"","keywords":"Cancer research; Biology; Neural crest; Wnt signaling pathway; Transcription factor; Cell biology; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002616,0.0003429006,0.0006573541,0.0003714642,0.0003205937,0.0005205306,0.000376582,0.0004504308,0.005341594],"category_scores_gemma":[0.0001929615,0.000174779,0.000413579,0.0003096475,0.0003087431,0.0001694104,0.0002739125,0.001061675,0.001533032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004914199,"about_ca_system_score_gemma":0.0009373821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001639167,"about_ca_topic_score_gemma":0.003356464,"domain_scores_codex":[0.9998198,0.00001718974,0.00001236754,0.00003184863,0.00006189979,0.00005689471],"domain_scores_gemma":[0.9998085,0.00001711678,0.00002700856,0.00001972601,0.00002055499,0.0001071782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006836765,0.001105051,0.01729354,0.000423417,0.0001010309,0.0005647399,0.00008612556,0.001002789,0.9277205,0.0003973839,0.004967003,0.03950166],"study_design_scores_gemma":[0.001094871,0.01183359,0.1682353,0.00008513971,0.0002902948,0.003595211,0.0002730576,0.006915057,0.7786031,0.0006305441,0.02839335,0.00005040211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871253,0.002116391,0.0008268291,0.0003902875,0.0001342476,0.0001430827,0.003871548,0.0006103123,0.004781884],"genre_scores_gemma":[0.9871337,0.0008502326,0.001290231,0.000325661,0.00002055695,0.0001778902,0.005909357,0.00005979199,0.004232603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005341594,"threshold_uncertainty_score":0.01786941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0148277940399396,"score_gpt":0.284706817355861,"score_spread":0.2698790233159214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}