{"id":"W4388590054","doi":"10.1093/neuonc/noad179.0340","title":"CTNI-58. UPDATED RESULTS AND MOLECULAR SUBGROUP ANALYSES FROM THE RANDOMIZED PHASE 3 MIRAGE TRIAL ON MARIZOMIB IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Princess Margaret Cancer Centre; Centre hospitalier universitaire de Québec; Centre Hospitalier de l’Université de Montréal; Health Sciences Centre; Queen's University; McMaster University; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Temozolomide; Medicine; Concomitant; Internal medicine; Oncology; Interim analysis; Randomized controlled trial; Chemotherapy; Isocitrate dehydrogenase; O-6-methylguanine-DNA methyltransferase; Radiation therapy; Methyltransferase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004777731,0.001614576,0.003867662,0.0008720459,0.0003013831,0.00119278,0.0009014597,0.0008161814,0.004281307],"category_scores_gemma":[0.004376997,0.0004319291,0.006179027,0.0011391,0.0003732725,0.000896144,0.0006091261,0.001554474,0.0004736888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007102265,"about_ca_system_score_gemma":0.001100762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001206466,"about_ca_topic_score_gemma":0.00562347,"domain_scores_codex":[0.9974945,0.001511957,0.0002357043,0.0003331021,0.0002172478,0.0002075973],"domain_scores_gemma":[0.9981852,0.0006740972,0.0005672847,0.0002160021,0.0001079068,0.0002495449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8762433,0.0004354535,0.02759446,0.00302054,0.03271719,0.0002073085,0.00006543921,0.00171112,0.003573901,0.0002434081,0.005023695,0.04916434],"study_design_scores_gemma":[0.6441959,0.03390703,0.1700747,0.0007242421,0.128437,0.0005713534,0.0001739725,0.004349584,0.002106673,0.002540538,0.01272506,0.0001939419],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8911352,0.08612662,0.001801809,0.002047783,0.001149267,0.001636395,0.01085684,0.0002476714,0.004998423],"genre_scores_gemma":[0.9735371,0.009165917,0.001551825,0.001256968,0.0007842735,0.001743597,0.01005094,0.00007115596,0.001838224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004777731,"threshold_uncertainty_score":0.02526736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02232135240279522,"score_gpt":0.3204310996465501,"score_spread":0.2981097472437549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}