{"id":"W4388590430","doi":"10.1093/neuonc/noad179.0569","title":"IMMU-37. TARGETING NON-CATALYTIC ACTIVATORS OF THE PROTEASOME DECREASES TUMOR GROWTH AND ENHANCES ANTIGEN PRESENTATION IN GLIOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Neurosciences, Mental Health and Addiction; Government of Canada; University of Calgary","funders":"","keywords":"Proteasome; Proteostasis; Biology; Cancer research; Cell biology; Neural stem cell; Stem cell; Activator (genetics); Downregulation and upregulation; In vivo; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001305933,0.0004865904,0.000428866,0.000350606,0.0001206213,0.0003044672,0.0002367806,0.0002119021,0.001511786],"category_scores_gemma":[0.00008497611,0.0001296599,0.0002603177,0.0002713734,0.000255301,0.0001420001,0.0001374444,0.0006484715,0.0004587377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004772773,"about_ca_system_score_gemma":0.000543893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001451492,"about_ca_topic_score_gemma":0.002370767,"domain_scores_codex":[0.9998536,0.00001571115,0.00001461647,0.00002289516,0.00004448033,0.00004867286],"domain_scores_gemma":[0.9999359,0.00000709669,0.00001342005,0.000006806218,0.000007875641,0.00002888154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004796585,0.0001716944,0.000249409,0.00009255861,0.00001312296,0.00004239942,0.00001206671,0.0001404529,0.9951897,0.00008250678,0.0002174065,0.003308917],"study_design_scores_gemma":[0.00003787353,0.001195521,0.001916599,0.000007500866,0.00003146691,0.0001087562,0.00001893228,0.0006740243,0.9933989,0.00004421973,0.002561888,0.000004276584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902498,0.004756152,0.001684047,0.0002000949,0.0001300887,0.0000481,0.0008289986,0.00030618,0.001796464],"genre_scores_gemma":[0.9931127,0.001911548,0.001457194,0.00009255415,0.00001401132,0.0000405479,0.001115967,0.00003228299,0.002223251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001511786,"threshold_uncertainty_score":0.005057395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052500384115085,"score_gpt":0.2665183434337563,"score_spread":0.2559933395926055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}