{"id":"W4388590609","doi":"10.1093/neuonc/noad179.0135","title":"STEM-09. EXPLORING THE ROLE OF <i>TP53</i> IN REDOX REGULATION AND RESPONSE OF GLIOBLASTOMA STEM CELLS TO ROS-INDUCING AGENTS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Gene knockdown; Auranofin; Thioredoxin; Cancer research; Stem cell; Neurosphere; Reactive oxygen species; Radioresistance; Glutathione; Biology; Chemistry; Molecular biology; Cell culture; Oxidative stress; Cell biology; Immunology; Biochemistry; Cellular differentiation; Gene; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001937271,0.0002374265,0.0002701719,0.0003737969,0.0001938171,0.0004171694,0.0001772058,0.0003492183,0.002989369],"category_scores_gemma":[0.0001191628,0.000118376,0.0002469907,0.0002659035,0.0002095604,0.0002118056,0.0001430104,0.0003832222,0.0006352533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003138318,"about_ca_system_score_gemma":0.0002576514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006798613,"about_ca_topic_score_gemma":0.0007614861,"domain_scores_codex":[0.9998968,0.00001028857,0.00001107296,0.00002204422,0.0000401631,0.00001962983],"domain_scores_gemma":[0.9999096,0.00001200968,0.00002514768,0.000006489341,0.00002139828,0.00002530159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002606656,0.00006686171,0.001491218,0.0001591069,0.00001231362,0.0001498638,0.0000413028,0.0001058538,0.98804,0.0002887716,0.000377551,0.009006348],"study_design_scores_gemma":[0.0000256318,0.0006545552,0.01163644,0.00001613364,0.00003590962,0.0004473133,0.00007021327,0.00111283,0.9763837,0.0001700002,0.009442042,0.00000531074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808148,0.004996407,0.004574483,0.000525746,0.0001186322,0.0001617423,0.002599932,0.0004725466,0.005735619],"genre_scores_gemma":[0.9868742,0.001826925,0.003164604,0.0002730254,0.00001902702,0.0001122234,0.003398456,0.00004069993,0.004290799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002989369,"threshold_uncertainty_score":0.01000047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03061039035825424,"score_gpt":0.298693212859479,"score_spread":0.2680828225012247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}