{"id":"W4388590642","doi":"10.1093/neuonc/noad179.0134","title":"STEM-08. OVERCOMING GLIOBLASTOMA STEM CELL RESISTANCE TO RADIATION THROUGH TARGETING THIOREDOXIN REDUCTASE 1","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Radioresistance; Cancer research; Stem cell; RAD51; Viability assay; Thioredoxin reductase; Reactive oxygen species; DNA damage; Thioredoxin; Biology; Auranofin; Chemistry; Molecular biology; Immunology; Oxidative stress; Cell; Cell culture; Cell biology; Biochemistry; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004394208,0.0002719822,0.0003238967,0.0001013691,0.0002422986,0.00002275895,0.0003598607,0.0004202779,0.00001496718],"category_scores_gemma":[0.0001372272,0.0002718465,0.0001165497,0.0004122414,0.0001270843,0.00001442719,0.0002785935,0.0002711079,0.0001881909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007357811,"about_ca_system_score_gemma":0.000165954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005988417,"about_ca_topic_score_gemma":0.00004474345,"domain_scores_codex":[0.9974665,0.0005238913,0.0004645266,0.0008240686,0.0001455179,0.0005754616],"domain_scores_gemma":[0.9988576,0.0001991051,0.0002495095,0.0004594907,0.00009583955,0.0001384927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008040444,0.00004897742,0.0003308931,0.00002323382,0.00002380676,0.00008008827,0.0004642755,0.0002859612,0.9147878,0.0000861133,0.07867891,0.00438584],"study_design_scores_gemma":[0.0006209125,0.0007139057,0.0001218867,0.000007940296,0.00001185043,0.000008983735,0.000549367,0.0000206094,0.6178338,0.00003715751,0.3798896,0.0001840309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908184,0.0006426827,0.0003525437,0.001704459,0.00110221,0.0004337246,0.000136067,0.00009266561,0.00471729],"genre_scores_gemma":[0.994471,0.0005074131,0.0005688323,0.001675145,0.0007392715,0.00008819909,0.0001867704,0.00004945187,0.001713922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3012107,"threshold_uncertainty_score":0.9999734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01399601538408759,"score_gpt":0.2814658345402434,"score_spread":0.2674698191561558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}