{"id":"W4388590642","doi":"10.1093/neuonc/noad179.0134","title":"STEM-08. OVERCOMING GLIOBLASTOMA STEM CELL RESISTANCE TO RADIATION THROUGH TARGETING THIOREDOXIN REDUCTASE 1","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Radioresistance; Cancer research; Stem cell; RAD51; Viability assay; Thioredoxin reductase; Reactive oxygen species; DNA damage; Thioredoxin; Biology; Auranofin; Chemistry; Molecular biology; Immunology; Oxidative stress; Cell; Cell culture; Cell biology; Biochemistry; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002004469,0.0003622458,0.000418344,0.0005107338,0.0001913904,0.0004162147,0.000257969,0.0004188021,0.002651017],"category_scores_gemma":[0.0001054824,0.0001232931,0.0003857219,0.0003115073,0.0002243856,0.0002177573,0.0002278108,0.0006915912,0.0006317896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003120581,"about_ca_system_score_gemma":0.0003648915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006425508,"about_ca_topic_score_gemma":0.00121515,"domain_scores_codex":[0.9998914,0.000009569163,0.000009812498,0.00002137592,0.00004396747,0.0000238339],"domain_scores_gemma":[0.9999464,0.000005737026,0.00001432329,0.000003875489,0.00001461705,0.00001503439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006200854,0.0004408664,0.002476855,0.001316741,0.00008884165,0.0004821046,0.0001865869,0.0007903854,0.8665215,0.002208989,0.005021368,0.1198456],"study_design_scores_gemma":[0.0003252547,0.003835402,0.0118456,0.0001041726,0.0003379467,0.001798089,0.0001498068,0.003997005,0.8861859,0.0009171664,0.0904766,0.00002707084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9262164,0.03718569,0.01530299,0.002661643,0.0009612382,0.0005907599,0.002095717,0.001686418,0.01329909],"genre_scores_gemma":[0.9719344,0.009765562,0.006789007,0.0007874563,0.00009613147,0.0002178625,0.002507888,0.00004155192,0.00786016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002651017,"threshold_uncertainty_score":0.008868515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01399601538408759,"score_gpt":0.2814658345402434,"score_spread":0.2674698191561558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}