{"id":"W4388590663","doi":"10.1093/neuonc/noad179.0357","title":"CTNI-75. EFFICACY AND SAFETY OF LAROTRECTINIB IN PATIENTS WITH TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS: AN UPDATED ANALYSIS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bayer (Canada); Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Trk receptor; Internal medicine; Glioma; Oncology; Clinical endpoint; Gastroenterology; Clinical trial; Surgery; Receptor; Neurotrophin; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001886492,0.0002501316,0.0009446307,0.0006239646,0.00007504467,0.00001118574,0.00009084032,0.000155987,0.0000795467],"category_scores_gemma":[0.0000611343,0.0001907371,0.00009682153,0.001590258,0.00009324405,0.00007441354,0.00008242941,0.0002100518,0.00001355503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004070559,"about_ca_system_score_gemma":0.0001338808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000289587,"about_ca_topic_score_gemma":0.0001811448,"domain_scores_codex":[0.9977459,0.0004016703,0.0005524306,0.0005558988,0.0003009565,0.0004431297],"domain_scores_gemma":[0.9987513,0.0002170136,0.0002569887,0.0003871137,0.0001197843,0.0002678119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005254722,0.003409885,0.9372909,0.0001122666,0.0003974072,0.000786603,0.0005475795,0.0002624148,0.02702928,0.00002620089,0.0005243709,0.02435839],"study_design_scores_gemma":[0.01377042,0.005020139,0.9748805,0.00009868541,0.0008177612,0.00001750427,0.0002450274,0.0003350716,0.003308824,6.284426e-7,0.001358988,0.000146417],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978362,0.00003915175,0.000002379868,0.0004156084,0.0001558683,0.001134628,0.00007481323,0.0001187587,0.0002225936],"genre_scores_gemma":[0.9983317,0.00004093175,0.000169436,0.0001572586,0.00005005248,0.00005554704,0.001152154,0.0000357379,0.000007177915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03758965,"threshold_uncertainty_score":0.7778034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009833608865202266,"score_gpt":0.2546425590367992,"score_spread":0.2448089501715969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}