{"id":"W4388590663","doi":"10.1093/neuonc/noad179.0357","title":"CTNI-75. EFFICACY AND SAFETY OF LAROTRECTINIB IN PATIENTS WITH TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS: AN UPDATED ANALYSIS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bayer (Canada); Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Trk receptor; Internal medicine; Glioma; Oncology; Clinical endpoint; Gastroenterology; Clinical trial; Surgery; Receptor; Neurotrophin; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0037866,0.0005259775,0.001536733,0.001675524,0.0001940728,0.001296015,0.0007768561,0.000367991,0.002206368],"category_scores_gemma":[0.002858771,0.0002302346,0.002473075,0.00246657,0.0003139515,0.0006947536,0.0002765592,0.0008152045,0.0005678945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002297408,"about_ca_system_score_gemma":0.001364599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00303113,"about_ca_topic_score_gemma":0.01031849,"domain_scores_codex":[0.9984092,0.0003823324,0.0002271247,0.0002792683,0.0005905257,0.0001115202],"domain_scores_gemma":[0.9963883,0.0009724106,0.001781584,0.000106995,0.0005356732,0.000215013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.04249519,0.0005369982,0.2496645,0.01910021,0.03209551,0.0007189087,0.0002535458,0.004732255,0.01699234,0.0007277993,0.03281312,0.5998696],"study_design_scores_gemma":[0.01298336,0.01194634,0.816362,0.002984754,0.05138924,0.003365403,0.0001464034,0.003267139,0.005854837,0.0005962612,0.09091613,0.0001881241],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5286356,0.4082872,0.001839816,0.001719636,0.0002386193,0.001481892,0.03382647,0.0002691452,0.02370163],"genre_scores_gemma":[0.8928819,0.06994778,0.002098649,0.002255088,0.0003522264,0.0005648554,0.02946417,0.00006800536,0.002367432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0037866,"threshold_uncertainty_score":0.02002567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009833608865202266,"score_gpt":0.2546425590367992,"score_spread":0.2448089501715969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}