{"id":"W4388590696","doi":"10.1093/neuonc/noad179.0862","title":"EXTH-08. IMMUNOTHERAPEUTIC TARGETING OF FIBROBLAST ACTIVATION PROTEIN (FAP) IN TREATMENT REFRACTORY GLIOBLASTOMA USING NOVEL CAR-T CELL THERAPY","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Fibroblast activation protein, alpha; Chimeric antigen receptor; Cancer research; U87; Medicine; Stromal cell; Glioma; Antigen; Immunotherapy; Immunology; Cancer; Internal medicine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001628106,0.0002888294,0.0003629063,0.0002214284,0.0001282046,0.0002318415,0.0002858682,0.0004392105,0.001658312],"category_scores_gemma":[0.00006177872,0.0000810163,0.0002761337,0.000143166,0.0001596761,0.000151067,0.0001592735,0.0004966041,0.000508066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002577713,"about_ca_system_score_gemma":0.0003442719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001052659,"about_ca_topic_score_gemma":0.001238685,"domain_scores_codex":[0.9999288,0.00001074686,0.000004398511,0.00001316084,0.0000149487,0.00002791214],"domain_scores_gemma":[0.9999734,0.000003123377,0.000004391242,0.000003324888,0.000004384371,0.00001130798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00151755,0.001289651,0.001235858,0.0004824248,0.00006098651,0.0009682173,0.0001350411,0.001731199,0.9179544,0.001133595,0.003203559,0.07028756],"study_design_scores_gemma":[0.00114084,0.01414008,0.00736773,0.00005308406,0.0002116832,0.003744371,0.00007637393,0.009254313,0.9264969,0.0003946069,0.03708878,0.00003117786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820067,0.005247014,0.005919914,0.0004735262,0.0001869792,0.0003913626,0.0006703294,0.0002635877,0.004840663],"genre_scores_gemma":[0.9872765,0.002077461,0.004075967,0.0002568029,0.00003685764,0.0002706627,0.001079768,0.00002879145,0.004897233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001658312,"threshold_uncertainty_score":0.005547643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05985623119210558,"score_gpt":0.3477529791566311,"score_spread":0.2878967479645255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}