{"id":"W4388592087","doi":"10.1161/circep.123.012567","title":"Multicenter, Phase 2, Randomized Controlled Study of the Efficacy and Safety of Etripamil Nasal Spray for the Acute Reduction of Rapid Ventricular Rate in Patients With Symptomatic Atrial Fibrillation (ReVeRA-201)","year":2023,"lang":"en","type":"article","venue":"Circulation Arrhythmia and Electrophysiology","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vertex Pharmaceuticals (Canada); Centre Hospitalier Universitaire de Sherbrooke; Montreal Heart Institute; Public Health Ontario","funders":"Boston Scientific Corporation; American Heart Association; Sanofi; GlaxoSmithKline; Pfizer; Daiichi Sankyo Europe; Bristol-Myers Squibb","keywords":"Medicine; Placebo; Adverse effect; Atrial fibrillation; Randomized controlled trial; Heart rate; Anesthesia; Nasal administration; Cardiology; Internal medicine; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005472772,0.0001209204,0.0008984975,0.0001799832,0.00008305177,0.000004068173,0.0000308423,0.00005514443,0.000004583468],"category_scores_gemma":[0.000459028,0.00006430541,0.0001817265,0.0004114217,0.0001044476,0.00005241048,0.00002105893,0.0000543416,2.184061e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002092123,"about_ca_system_score_gemma":0.00002947147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000785282,"about_ca_topic_score_gemma":8.043266e-7,"domain_scores_codex":[0.998469,0.0003992309,0.0006732715,0.0001730258,0.0001603033,0.000125166],"domain_scores_gemma":[0.9980121,0.001044174,0.0006073094,0.00016364,0.0001536752,0.0000191489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8975493,0.00008426863,0.03798836,0.0002195283,0.002594213,0.000001333815,0.0009270581,0.01708322,0.03525858,0.0003050883,0.000009577464,0.007979529],"study_design_scores_gemma":[0.4505801,0.001166768,0.5262541,0.00004120366,0.001026483,0.000001147163,0.00007460405,0.02052184,0.0002070505,0.00005958799,0.00000929499,0.00005782435],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928682,0.0001714906,0.0002148756,0.0002538468,0.0001706464,0.006303884,0.000004088255,0.0000110196,0.000001976436],"genre_scores_gemma":[0.999526,0.0001744136,0.00002199111,0.000006244808,0.000187726,0.00001459477,0.00004508271,0.000009783017,0.00001420547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4882658,"threshold_uncertainty_score":0.2622299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256061098839657,"score_gpt":0.2813638615924962,"score_spread":0.2688032506040996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}