{"id":"W4388593449","doi":"10.1002/gcc.23213","title":"Rethinking cancer initiation: The role of large‐scale mutational events","year":2023,"lang":"en","type":"article","venue":"Genes Chromosomes and Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Carcinogenesis; Epigenetics; Biology; Cancer; Genetics; Gene; Somatic cell; Somatic evolution in cancer; Chromothripsis; Mutation; Point mutation; Genome; Phenotype; Cancer research; Computational biology; Genome instability; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009571797,0.00008650149,0.00009306032,0.0000220248,0.0001200325,0.00001222386,0.00009831809,0.00006451863,0.00008772062],"category_scores_gemma":[0.00001146071,0.00006952682,0.00004778304,0.0001182557,0.00004513098,0.000003481833,0.0001063196,0.00004013997,0.000002590733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001376074,"about_ca_system_score_gemma":0.000135706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001082858,"about_ca_topic_score_gemma":0.0005075184,"domain_scores_codex":[0.9993873,0.00001738003,0.0001339695,0.0001836218,0.0001166919,0.0001610341],"domain_scores_gemma":[0.9996547,0.00002175681,0.00007540215,0.000138391,0.00007497252,0.00003474797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001673614,0.0001081269,0.2654555,0.0002002558,0.0004814617,0.000005899064,0.006225297,0.007253885,0.5500466,0.002045074,0.009197369,0.1588131],"study_design_scores_gemma":[0.001458024,0.0001645001,0.1267182,0.0001093446,0.0001216111,0.00001317902,0.001852368,0.001792134,0.3689039,0.008967766,0.4894096,0.0004893318],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680147,0.03042996,0.00002122975,0.0005910424,0.0002754461,0.0001054875,0.000340729,0.000007761556,0.0002136314],"genre_scores_gemma":[0.9707095,0.02777718,0.00003994661,0.0004142686,0.0005500115,0.0001131515,0.0001342047,0.00001503462,0.0002466978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4802122,"threshold_uncertainty_score":0.2835222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129990353382042,"score_gpt":0.272547709821127,"score_spread":0.2612478062873065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}