{"id":"W4388593449","doi":"10.1002/gcc.23213","title":"Rethinking cancer initiation: The role of large‐scale mutational events","year":2023,"lang":"en","type":"article","venue":"Genes Chromosomes and Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Carcinogenesis; Epigenetics; Biology; Cancer; Genetics; Gene; Somatic cell; Somatic evolution in cancer; Chromothripsis; Mutation; Point mutation; Genome; Phenotype; Cancer research; Computational biology; Genome instability; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002515905,0.0006414219,0.00130953,0.001395809,0.00122213,0.00406978,0.001369809,0.002452444,0.00110029],"category_scores_gemma":[0.002500483,0.0003598771,0.0006216404,0.0009696591,0.01235832,0.01148926,0.003707808,0.006429516,0.0004367047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001913238,"about_ca_system_score_gemma":0.001346594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001278729,"about_ca_topic_score_gemma":0.001687774,"domain_scores_codex":[0.9989516,0.0002727583,0.0000634091,0.0002953735,0.0002885384,0.0001283805],"domain_scores_gemma":[0.9968823,0.001913309,0.0002975462,0.0004311895,0.0002440909,0.0002315876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002537321,0.00009971857,0.007638874,0.002470407,0.0001250571,0.002200545,0.005114679,0.003695419,0.05263529,0.6686475,0.01143935,0.2456794],"study_design_scores_gemma":[0.00003177766,0.0002908241,0.01259659,0.0009319417,0.0001127305,0.00375833,0.003259451,0.005173917,0.01216253,0.6789031,0.2826034,0.0001755194],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.07832662,0.7142516,0.07978185,0.0962442,0.006452201,0.00006174674,0.0001718319,0.0005066543,0.02420333],"genre_scores_gemma":[0.5918885,0.3507831,0.02292903,0.01594379,0.008455567,0.0001085528,0.0001062892,0.0002107425,0.00957438],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00406978,"threshold_uncertainty_score":0.01388156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129990353382042,"score_gpt":0.272547709821127,"score_spread":0.2612478062873065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}