{"id":"W4388594227","doi":"10.1101/2023.11.10.23298334","title":"Elevated Plasma Complement Factors in <i>CRB1</i> -associated Inherited Retinal Dystrophies","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"European Commission; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Complement factor I; Biology; Factor H; Genotype; Complement system; Complement component 3; Cohort; Complement factor B; Serpin; Internal medicine; Allele; Immunology; Genetics; Medicine; Gene; Antibody; Alternative complement pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003950926,0.0006339034,0.0004158177,0.0007142979,0.0003860634,0.0004960683,0.000245243,0.0003891456,0.002010887],"category_scores_gemma":[0.001034321,0.000208849,0.0002766723,0.0006738671,0.0003008202,0.0001647043,0.0002472984,0.0002642487,0.0001680573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000322625,"about_ca_system_score_gemma":0.0001700525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005455802,"about_ca_topic_score_gemma":0.003217969,"domain_scores_codex":[0.9996037,0.00006800392,0.00004317435,0.0001714863,0.00007268762,0.00004097735],"domain_scores_gemma":[0.999523,0.00007710937,0.0002678591,0.00002327517,0.00005436935,0.00005433731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001899974,0.0001026523,0.9683453,0.00008599303,0.0002505794,0.001632165,0.0001819731,0.00009700532,0.02228777,0.00008348405,0.0003295779,0.004703512],"study_design_scores_gemma":[0.00006778977,0.000297007,0.9938923,0.00001806327,0.0001123428,0.003431438,0.00009298277,0.0002666567,0.001393116,0.00003929081,0.0003828963,0.000006090853],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989694,0.0003198455,0.0001676237,0.00001884023,0.000004698188,0.00001063979,0.0002207846,0.000003921431,0.0002843037],"genre_scores_gemma":[0.9992775,0.00008730277,0.0002001174,0.00002387146,0.000008092931,0.000005985237,0.0002175243,0.000002846877,0.0001767356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005455802,"threshold_uncertainty_score":0.01084805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06455691684207433,"score_gpt":0.3170487650253916,"score_spread":0.2524918481833173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}