{"id":"W4388598233","doi":"10.1016/j.rpth.2023.100400","title":"OC 53.4 An siRNA Gene Therapy to Modulate Circulating Plasminogen Activator Inhibitor 1","year":2023,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"","keywords":"Genetic enhancement; Plasminogen activator; Plasminogen activator inhibitor-1; Pharmacology; Activator (genetics); Chemistry; Medicine; Cancer research; Gene; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002613996,0.0004831481,0.0006142239,0.0003530327,0.0001888634,0.0005316467,0.0002211723,0.0005254045,0.006473707],"category_scores_gemma":[0.0002389114,0.0001097092,0.0003307147,0.000194041,0.0004206528,0.0002156722,0.000136444,0.0007523689,0.00116017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003840859,"about_ca_system_score_gemma":0.0004303021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009300909,"about_ca_topic_score_gemma":0.001137612,"domain_scores_codex":[0.9997751,0.00002415476,0.00002309048,0.00005795752,0.00005581795,0.0000638314],"domain_scores_gemma":[0.9998913,0.00002860204,0.00002794931,0.00001440054,0.00001068646,0.00002704348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001175645,0.0003433623,0.0004236129,0.0001812108,0.0000383121,0.0001562118,0.00003704073,0.0002138798,0.9762667,0.0007223539,0.001599131,0.01884247],"study_design_scores_gemma":[0.0003613086,0.004216098,0.004614835,0.00004181876,0.0002041742,0.0007512185,0.00005679042,0.001712576,0.9701408,0.0002199452,0.01766153,0.00001906416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9587619,0.00506058,0.009897349,0.001252482,0.001041654,0.0003293639,0.001676042,0.0009486946,0.02103195],"genre_scores_gemma":[0.9844086,0.001669889,0.003102309,0.000468354,0.00008434621,0.0002680888,0.0007558565,0.0000847927,0.009157865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006473707,"threshold_uncertainty_score":0.02165675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2102726639311316,"score_gpt":0.4452991939453792,"score_spread":0.2350265300142476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}