{"id":"W4388598377","doi":"10.1016/j.rpth.2023.100452","title":"OC 52.3 Efficacy and Safety of Fidanacogene Elaparvovec in Adults with Moderately Severe or Severe Hemophilia B: Results from the Phase 3 BENEGENE-2 Gene Therapy Trial","year":2023,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Phase (matter); Genetic enhancement; Internal medicine; Gene; Biology; Genetics; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000359227,0.0002173958,0.0004081561,0.0001561112,0.0001409594,0.0004890465,0.0001556411,0.0004693063,0.005298687],"category_scores_gemma":[0.0004606535,0.00008131513,0.0003853547,0.0001464648,0.0002333887,0.0002203734,0.00009217988,0.0008240828,0.0007492504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002226064,"about_ca_system_score_gemma":0.0001811871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000483699,"about_ca_topic_score_gemma":0.001017883,"domain_scores_codex":[0.999885,0.00003799973,0.000005989927,0.00001418309,0.00002805235,0.00002884247],"domain_scores_gemma":[0.9998533,0.00003825293,0.00003290618,0.000009619597,0.000008720203,0.00005731076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2605312,0.007497852,0.01085782,0.001896982,0.001309559,0.0003960165,0.0002210919,0.0009972806,0.03964135,0.001172865,0.01973234,0.6557456],"study_design_scores_gemma":[0.4404863,0.2973569,0.1841263,0.0008611697,0.002524213,0.003984774,0.0003085245,0.002516751,0.0159949,0.001260003,0.05046827,0.0001119861],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9645396,0.02030436,0.0002874375,0.00111096,0.0001661108,0.0002872465,0.001436971,0.0001395349,0.01172775],"genre_scores_gemma":[0.9902811,0.003612221,0.0004022806,0.001026385,0.0001089548,0.0001497979,0.0009461351,0.00001532364,0.003457797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005298687,"threshold_uncertainty_score":0.01772583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2169261472418067,"score_gpt":0.451659390859095,"score_spread":0.2347332436172883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}