{"id":"W4388598643","doi":"10.1016/j.rpth.2023.100449","title":"OC 20.3 Improved Joint Health After Gene Therapy with Dirloctocogene Samoparvovec (SPK-8011) in People with Hemophilia A","year":2023,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Joint (building); Internal medicine; Genetic enhancement; Oncology; Gene; Genetics; Biology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003163093,0.0002261265,0.0004932201,0.0002469478,0.0002545723,0.0003305578,0.0001324885,0.00034232,0.005352785],"category_scores_gemma":[0.0004939504,0.00008440312,0.0004321058,0.00027818,0.0001523119,0.0001248077,0.0001709076,0.0002837161,0.0004820376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001964207,"about_ca_system_score_gemma":0.0001645238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002058766,"about_ca_topic_score_gemma":0.00160935,"domain_scores_codex":[0.9998316,0.00004133889,0.00001021792,0.00002526627,0.00003869913,0.00005277914],"domain_scores_gemma":[0.9998783,0.00002302465,0.00003282505,0.00000848208,0.00002181631,0.0000355696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.08722817,0.01023678,0.1225915,0.002400949,0.001166826,0.001247019,0.001466226,0.0004463168,0.1647449,0.0004768407,0.00773215,0.6002623],"study_design_scores_gemma":[0.006077047,0.1191506,0.8191401,0.0004411092,0.002221443,0.002935951,0.001250223,0.0007507025,0.02480059,0.0006209252,0.02253746,0.00007397348],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931605,0.002965773,0.0001337327,0.0001692777,0.00007649907,0.00004567637,0.0003586017,0.00003674472,0.003053318],"genre_scores_gemma":[0.9959888,0.0008983397,0.0001976175,0.0001336504,0.00002315154,0.00004558942,0.0002553222,0.000006683623,0.002450848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005352785,"threshold_uncertainty_score":0.0179069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1741219490815399,"score_gpt":0.4406092187003299,"score_spread":0.26648726961879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}