{"id":"W4388598651","doi":"10.1016/j.rpth.2023.100429","title":"OC 20.2 Gene Therapy in Hemophilia A: The Impact of Valoctocogene Roxaparvovec on Patient Outcomes – Initial Results from Patient Reported Outcomes, Burdens and Experiences (PROBE) from the GENEr8-1 Trial","year":2023,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Impact","funders":"","keywords":"Medicine; Internal medicine; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001004104,0.0003334504,0.0005953966,0.0001730474,0.0001133912,0.0006967789,0.0002096969,0.0005287402,0.002309843],"category_scores_gemma":[0.001194828,0.00007045965,0.0006717137,0.0002336414,0.0004513098,0.000473722,0.0002111861,0.001109156,0.0002661699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004562033,"about_ca_system_score_gemma":0.0003396933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003661551,"about_ca_topic_score_gemma":0.0007285894,"domain_scores_codex":[0.999582,0.0002136769,0.00001763795,0.00003864743,0.00007493,0.00007305595],"domain_scores_gemma":[0.9995284,0.0001943215,0.0001477535,0.00002983651,0.0000185458,0.0000810674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.469967,0.01111111,0.01492882,0.001537775,0.002872228,0.0002346972,0.0002525899,0.002419835,0.01982273,0.002255474,0.008976074,0.4656217],"study_design_scores_gemma":[0.4421325,0.3733856,0.1266622,0.0009660583,0.004855009,0.001163729,0.0004741026,0.003535602,0.01367333,0.002634985,0.03038429,0.0001326135],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98843,0.007279105,0.0001419302,0.0008713172,0.00008847393,0.00009623007,0.0004340912,0.00001979621,0.002638918],"genre_scores_gemma":[0.9911304,0.004766894,0.0004959306,0.0007485893,0.0001796928,0.0002382007,0.0007984152,0.00001414185,0.001627805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002309843,"threshold_uncertainty_score":0.007727146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2691005891358715,"score_gpt":0.4842347981618682,"score_spread":0.2151342090259967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}