{"id":"W4388599422","doi":"10.1101/2023.11.10.566607","title":"OOCYTE AND EMBRYO CULTURE UNDER OIL PROFOUNDLY ALTERS EFFECTIVE CONCENTRATIONS OF SMALL MOLECULE INHIBITORS","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Université de Montréal; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Nocodazole; Oocyte; Embryo; Embryo culture; Cell culture; Cell biology; Biology; Chemistry; Embryogenesis; Cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003649742,0.0003751994,0.0003710049,0.0002644561,0.000189835,0.0006667525,0.0003513714,0.000354695,0.001938362],"category_scores_gemma":[0.000803196,0.0001793398,0.0001615085,0.0001865202,0.0003732626,0.0003589972,0.0004158344,0.0005925837,0.0005637532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003300124,"about_ca_system_score_gemma":0.0003633877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001396267,"about_ca_topic_score_gemma":0.0023282,"domain_scores_codex":[0.9995236,0.00009129651,0.00005661041,0.00009739144,0.0001667433,0.00006435094],"domain_scores_gemma":[0.9994803,0.0002626117,0.00008950809,0.0000541593,0.00005937297,0.00005408415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001100659,0.00001624167,0.0001308313,0.00004135764,0.0000048098,0.00003064904,0.00002135216,0.00006087598,0.9985542,0.00005671825,0.00006542471,0.0009074565],"study_design_scores_gemma":[0.000008494306,0.0001845571,0.001470963,0.000007922375,0.00001320835,0.00005153357,0.0000245145,0.0003643335,0.995987,0.00002906916,0.001853629,0.000004723854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769095,0.004548131,0.009217439,0.0003639587,0.000161023,0.0001118731,0.00158489,0.000218161,0.00688508],"genre_scores_gemma":[0.9809644,0.002638388,0.009269805,0.0002434425,0.00002849595,0.0000940879,0.001304911,0.0002023594,0.005254031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001938362,"threshold_uncertainty_score":0.006484509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0190822919101217,"score_gpt":0.2497335552050438,"score_spread":0.2306512632949221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}