{"id":"W4388621682","doi":"10.1056/nejmoa2306185","title":"Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":263,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Ipsen; National Institute for Health and Care Research","keywords":"Ursodeoxycholic acid; Cholestasis; Gastroenterology; Alkaline phosphatase; Medicine; Internal medicine; Placebo; Clinical endpoint; Randomization; Bilirubin; Bile acid; Confidence interval; Primary biliary cirrhosis; Randomized controlled trial; Pathology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002454119,0.0005605352,0.002899685,0.0003290554,0.0003117872,0.0005629698,0.0003426661,0.001041515,0.003535058],"category_scores_gemma":[0.003249189,0.0003122334,0.001219966,0.0003260715,0.00080059,0.0005192672,0.0003275296,0.001647044,0.0006821973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004852488,"about_ca_system_score_gemma":0.0006959378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002801559,"about_ca_topic_score_gemma":0.0004056238,"domain_scores_codex":[0.9988217,0.0006294999,0.0001366272,0.0001126225,0.0001551238,0.0001444735],"domain_scores_gemma":[0.9979777,0.000729263,0.0005768449,0.0001348742,0.0001693994,0.0004119601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8218801,0.01199134,0.007200606,0.002113343,0.0008600074,0.0003149086,0.0002051805,0.0009728456,0.02910944,0.0001146049,0.0008129383,0.1244247],"study_design_scores_gemma":[0.4066602,0.5521372,0.02861454,0.0002110002,0.00103221,0.0007388569,0.0000851762,0.0009198433,0.007108629,0.0002014569,0.002256738,0.00003430197],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913429,0.005927181,0.000375156,0.0003568075,0.0001149787,0.0005939321,0.0001829505,0.00004132519,0.001064645],"genre_scores_gemma":[0.9960909,0.001804122,0.0004094607,0.0002483756,0.0002094855,0.0005199412,0.0001663483,0.000007582887,0.0005437322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003535058,"threshold_uncertainty_score":0.01297879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668709028783372,"score_gpt":0.269278088101723,"score_spread":0.2525909978138893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}