{"id":"W4388621682","doi":"10.1056/nejmoa2306185","title":"Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":263,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Ipsen; National Institute for Health and Care Research","keywords":"Ursodeoxycholic acid; Cholestasis; Gastroenterology; Alkaline phosphatase; Medicine; Internal medicine; Placebo; Clinical endpoint; Randomization; Bilirubin; Bile acid; Confidence interval; Primary biliary cirrhosis; Randomized controlled trial; Pathology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007621892,0.00008997251,0.0004753472,0.0003207687,0.00001954108,0.000002398514,0.00007111027,0.00004390746,0.000143382],"category_scores_gemma":[0.0004192415,0.0000576893,0.00005003145,0.0003458198,0.00009902339,0.00008632866,0.00003154501,0.0002755109,0.000002627909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000303437,"about_ca_system_score_gemma":0.0001714408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001213261,"about_ca_topic_score_gemma":0.000003692065,"domain_scores_codex":[0.9989269,0.00007141029,0.0004862814,0.00007675181,0.0003031555,0.0001354725],"domain_scores_gemma":[0.9990583,0.0003254528,0.0001642809,0.0001331198,0.00007801338,0.0002408378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01128874,0.0002853468,0.4712188,0.0005991132,0.0002756981,0.001175071,0.003223808,0.00002039326,0.02060048,0.00007287688,0.01427351,0.4769662],"study_design_scores_gemma":[0.06594614,0.001365977,0.9215922,0.001183057,0.0001564074,0.0005002844,0.0001735837,0.00001551994,0.0001254374,0.0001385169,0.008754684,0.00004820674],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897622,0.003396644,0.0000148484,0.004906676,0.0002021963,0.0001287366,0.000004500449,0.000009466305,0.0015747],"genre_scores_gemma":[0.9933569,0.004900437,0.0001087459,0.0003359656,0.000923401,3.006013e-7,0.00001658548,0.00001092381,0.0003467316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.476918,"threshold_uncertainty_score":0.2352501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668709028783372,"score_gpt":0.269278088101723,"score_spread":0.2525909978138893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}