{"id":"W4388625566","doi":"10.7554/elife.90333.3.sa4","title":"Author Response: Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Neurotrophin; Signalling; Neuroscience; Biology; Downstream (manufacturing); Cell biology; Internal medicine; Endocrinology; Medicine; Receptor; Genetics; Economics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001326411,0.000481142,0.0004408185,0.000768699,0.0006605274,0.001491513,0.0007169023,0.002034508,0.1162843],"category_scores_gemma":[0.009041941,0.0002141528,0.0002142964,0.0002840063,0.0008087176,0.0007754901,0.001148602,0.001777252,0.04604701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007078204,"about_ca_system_score_gemma":0.001656071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001206372,"about_ca_topic_score_gemma":0.002909665,"domain_scores_codex":[0.9987741,0.0001748899,0.00007802278,0.0001625052,0.0006631079,0.0001474674],"domain_scores_gemma":[0.9914091,0.0009252768,0.0005004812,0.0002943721,0.005460365,0.001410268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003855654,0.00003238626,0.00184324,0.000578811,0.00003492615,0.001130723,0.0001958923,0.0001667236,0.01321041,0.002162996,0.9164089,0.06384949],"study_design_scores_gemma":[0.00005030311,0.00006189443,0.004727325,0.0001437865,0.00001583945,0.00139993,0.0003674408,0.0002205177,0.005940171,0.001304937,0.9857424,0.00002542575],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"other","genre_scores_codex":[0.04413122,0.02257283,0.007402196,0.3797249,0.3872874,0.0004487608,0.006282561,0.002961725,0.1491884],"genre_scores_gemma":[0.0853151,0.009757392,0.002965823,0.01793681,0.03692195,0.00008737265,0.003245686,0.0007845396,0.8429853],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.1162843,"threshold_uncertainty_score":0.3890096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0394128411630844,"score_gpt":0.2873903008677909,"score_spread":0.2479774597047065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}