{"id":"W4388625690","doi":"10.25251/skin.7.supp.239","title":"Deucravacitinib, an Oral, Selective, Allosteric Tyrosine Kinase 2 Inhibitor, in Moderate to Severe Plaque Psoriasis: Absolute PASI Outcomes Over 52 Weeks in the Phase 3 POETYK PSO-1 Trial","year":2023,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; Queen's University","funders":"National Institute for Health and Care Research; Manchester Biomedical Research Centre; Bristol-Myers Squibb","keywords":"Apremilast; Medicine; Psoriasis; Placebo; Psoriasis Area and Severity Index; Internal medicine; Gastroenterology; Randomization; Randomized controlled trial; Plaque psoriasis; Pharmacology; Dermatology; Psoriatic arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001693667,0.0009425213,0.001604124,0.0001968673,0.0002908913,0.0008670011,0.0004890698,0.0009076025,0.00294102],"category_scores_gemma":[0.0009271155,0.0003107183,0.001866648,0.0002107729,0.0004824387,0.0007912853,0.0002530692,0.00255026,0.0004161705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005924759,"about_ca_system_score_gemma":0.000676486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005172683,"about_ca_topic_score_gemma":0.001415092,"domain_scores_codex":[0.9995222,0.0002292338,0.00003172767,0.00008433773,0.00005449451,0.00007802658],"domain_scores_gemma":[0.99946,0.0001227462,0.0001429792,0.00003579502,0.00004290014,0.0001955657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.917699,0.006597225,0.002723234,0.001235749,0.002173487,0.00009039004,0.0001142146,0.001113016,0.009373777,0.0002329944,0.003535746,0.05511108],"study_design_scores_gemma":[0.833173,0.1453516,0.01441442,0.0001151136,0.00124132,0.000260675,0.00004888297,0.00122729,0.001567895,0.0003623631,0.002203254,0.00003419109],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845894,0.008450186,0.0004315558,0.0006583394,0.0002355172,0.0012645,0.0009793235,0.0001063868,0.003284666],"genre_scores_gemma":[0.9934115,0.002113046,0.000454098,0.0005166705,0.0001731369,0.0008722225,0.0009347222,0.00001285677,0.001511693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00294102,"threshold_uncertainty_score":0.009838641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02818460525731643,"score_gpt":0.3072451829521908,"score_spread":0.2790605776948744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}