{"id":"W4388625787","doi":"10.1038/s41591-023-02611-1","title":"Viral and host mediators of non-suppressible HIV-1 viremia","year":2023,"lang":"en","type":"article","venue":"Nature Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of Washington; Michael Smith Health Research BC; Frederick National Laboratory for Cancer Research; University of Pittsburgh; Dana-Farber Cancer Institute; Harvard University Center for AIDS Research; Harvard University; National Cancer Institute; Case Western Reserve University; Brigham and Women's Hospital; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Viremia; Downregulation and upregulation; Virology; Biology; Viral load; Viral replication; CD8; Epigenetics; Gene; Virus; Immunology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000248455,0.0001493679,0.0001640465,0.000246956,0.0001728991,0.0004290487,0.0001559337,0.0001711518,0.001489494],"category_scores_gemma":[0.0002454694,0.00008281757,0.00009758848,0.0001280876,0.000210453,0.00016273,0.0002275746,0.0002637463,0.0001159276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001230636,"about_ca_system_score_gemma":0.000102293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002145904,"about_ca_topic_score_gemma":0.000204987,"domain_scores_codex":[0.9998786,0.00003787496,0.000008826408,0.00001958616,0.00003418691,0.0000207903],"domain_scores_gemma":[0.9998628,0.00003889237,0.00004846894,0.0000101797,0.00001781077,0.00002181878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001610814,0.0001779666,0.1383741,0.0001834571,0.00003386014,0.0006610101,0.0004256894,0.0002134687,0.8400929,0.0005486539,0.00009153014,0.01758646],"study_design_scores_gemma":[0.00009040132,0.002061478,0.7187066,0.00004617988,0.000107745,0.003559141,0.001141521,0.00197145,0.2681505,0.001266644,0.002877621,0.00002066671],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978016,0.0009652645,0.0003871214,0.00002078909,0.000004699942,0.00001806202,0.00009773541,0.000005973309,0.0006987167],"genre_scores_gemma":[0.9993839,0.0001150564,0.0002074837,0.000007520309,0.000004233475,0.000007995202,0.00005003759,0.000001236604,0.000222396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001489494,"threshold_uncertainty_score":0.004982829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005729316520486425,"score_gpt":0.2818751986698993,"score_spread":0.2761458821494129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}