{"id":"W4388625988","doi":"10.25251/skin.7.supp.254","title":"Apremilast in Pediatric Patients With Moderate to Severe Plaque Psoriasis: 16-Week Efficacy and Safety Results From the Phase 3, Randomized, Double-Blind, Placebo-Controlled SPROUT Study","year":2023,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stollery Children's Hospital; University of Alberta","funders":"Amgen","keywords":"Apremilast; Medicine; Double blind; Placebo; Psoriasis; Plaque psoriasis; Dermatology; Randomized controlled trial; Placebo-controlled study; Double blind study; Internal medicine; Alternative medicine; Pathology; Psoriatic arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002362434,0.001074304,0.002101415,0.0002482265,0.0003030228,0.000574566,0.0006125073,0.001090019,0.002304083],"category_scores_gemma":[0.001412276,0.0004441225,0.001537037,0.0003120054,0.0006632895,0.0007684925,0.0002545245,0.002549018,0.0004323375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003590743,"about_ca_system_score_gemma":0.001014869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000441965,"about_ca_topic_score_gemma":0.001263589,"domain_scores_codex":[0.9993506,0.0003593852,0.00005477221,0.0000815755,0.00008595989,0.0000676682],"domain_scores_gemma":[0.998784,0.0003188752,0.0003791388,0.00009826279,0.00008421534,0.0003355759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7738047,0.03403673,0.005518473,0.002501072,0.002150423,0.0004973854,0.0003019694,0.001311275,0.04892987,0.000192722,0.003055843,0.1276995],"study_design_scores_gemma":[0.6266333,0.3460801,0.01952459,0.00008851038,0.0006837124,0.0005513634,0.00006253766,0.0005184776,0.003996136,0.0001151017,0.001716764,0.00002942185],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893198,0.005646268,0.001016899,0.0004017887,0.0001112869,0.001669084,0.0008328281,0.0001505152,0.0008514698],"genre_scores_gemma":[0.9847847,0.006176056,0.003605505,0.0008886289,0.0003014262,0.001785318,0.001026794,0.0000531138,0.001378318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002362434,"threshold_uncertainty_score":0.01249385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01766693199130798,"score_gpt":0.2602192344788104,"score_spread":0.2425523024875024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}