{"id":"W4388626067","doi":"10.25251/skin.7.supp.257","title":"Efficacy and Safety of Risankizumab Compared with Apremilast in Patients with Moderate Plaque Psoriasis: Mean PASI and BSA Results From the Phase 4 IMMpulse Trial","year":2023,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of Toronto","funders":"Janssen Biotech; Glenmark Pharmaceuticals; LEO Pharma; Incyte; Dermira; Regeneron Pharmaceuticals; Celgene; Sanofi; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Psoriasis Area and Severity Index; Apremilast; Psoriasis; Randomized controlled trial; Body surface area; Plaque psoriasis; Internal medicine; Gastroenterology; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002613557,0.0008621912,0.001811241,0.0002417792,0.0002346445,0.0008623801,0.0005056828,0.0008231567,0.002866995],"category_scores_gemma":[0.001592859,0.0003636908,0.001415832,0.0002543428,0.0005592033,0.0006114723,0.0002857396,0.001781942,0.0004541646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004128065,"about_ca_system_score_gemma":0.0007743738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002273527,"about_ca_topic_score_gemma":0.0005754711,"domain_scores_codex":[0.9990764,0.0005280735,0.00007698265,0.0001188972,0.0001247667,0.00007490074],"domain_scores_gemma":[0.9991462,0.0002515276,0.0002657877,0.00005405885,0.00005660134,0.0002258527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9110917,0.008476712,0.003772473,0.00141278,0.001938981,0.0000729586,0.00008702106,0.0006628161,0.01365395,0.0001508809,0.001757213,0.05692243],"study_design_scores_gemma":[0.7091501,0.2693804,0.0154029,0.00009286835,0.001219093,0.0001896208,0.00003349564,0.0007232474,0.001943285,0.0002492851,0.001584115,0.00003153762],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854559,0.00909304,0.0004222442,0.0005516915,0.0001692288,0.001120462,0.0009528197,0.0001021496,0.002132429],"genre_scores_gemma":[0.9929777,0.002120311,0.0009151075,0.0007295671,0.0003135983,0.001070631,0.0009163096,0.0000142245,0.0009426257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002866995,"threshold_uncertainty_score":0.01382196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01372069000393474,"score_gpt":0.2400699069863114,"score_spread":0.2263492169823766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}