{"id":"W4388627262","doi":"10.1007/s40262-023-01319-2","title":"Pharmacokinetics, Safety, and Tolerability of Anti-SARS-CoV-2 Monoclonal Antibody, Sotrovimab, Delivered Intravenously or Intramuscularly in Japanese and Caucasian Healthy Volunteers","year":2023,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada)","funders":"Vir Biotechnology","keywords":"Medicine; Tolerability; Placebo; Pharmacokinetics; Confidence interval; Adverse effect; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002283985,0.0004780733,0.001477572,0.0004834445,0.0001079493,0.00005192383,0.0003668896,0.0003633881,0.00003330491],"category_scores_gemma":[0.001225968,0.0004229683,0.0002345703,0.001165306,0.001299982,0.0001414486,0.0004655971,0.001325408,0.00003497931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001182965,"about_ca_system_score_gemma":0.0005401382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006813012,"about_ca_topic_score_gemma":0.0001472293,"domain_scores_codex":[0.9947316,0.0004678398,0.002033565,0.001061595,0.0007453667,0.0009600442],"domain_scores_gemma":[0.9973015,0.001195831,0.0002561071,0.0005691671,0.0004031647,0.0002742553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0159362,0.002555195,0.5713625,0.002479679,0.0005141788,0.001508483,0.001770876,0.00002909627,0.3546715,0.00004102621,0.001775186,0.04735607],"study_design_scores_gemma":[0.05061587,0.007698814,0.6856277,0.0006630597,0.0009876892,0.0004756579,0.001225609,0.1155605,0.06973264,0.0003006148,0.06549625,0.001615638],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940698,0.0008856666,0.00008600014,0.002673971,0.0004856189,0.001339034,0.0001114701,0.0001306785,0.000217827],"genre_scores_gemma":[0.98117,0.00241839,0.0004256874,0.01544033,0.0003809434,0.00002132075,0.00004128913,0.00008026596,0.00002175069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2849389,"threshold_uncertainty_score":0.9998222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0855138984506186,"score_gpt":0.4492437812063357,"score_spread":0.363729882755717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}