{"id":"W4388627262","doi":"10.1007/s40262-023-01319-2","title":"Pharmacokinetics, Safety, and Tolerability of Anti-SARS-CoV-2 Monoclonal Antibody, Sotrovimab, Delivered Intravenously or Intramuscularly in Japanese and Caucasian Healthy Volunteers","year":2023,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada)","funders":"Vir Biotechnology","keywords":"Medicine; Tolerability; Placebo; Pharmacokinetics; Confidence interval; Adverse effect; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008406194,0.0003813797,0.0005667323,0.0001196399,0.0002633219,0.0003692815,0.0001749846,0.0005121119,0.001336903],"category_scores_gemma":[0.0007988007,0.0002520552,0.0003803034,0.0001480073,0.0004062178,0.0003255947,0.0001344744,0.0004257537,0.000263692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002799418,"about_ca_system_score_gemma":0.0005006555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001102977,"about_ca_topic_score_gemma":0.001600743,"domain_scores_codex":[0.9997206,0.0001022329,0.00002127529,0.00007780873,0.00004111446,0.00003681022],"domain_scores_gemma":[0.999657,0.00004752857,0.0001316549,0.00002613577,0.0000398481,0.00009783175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4650522,0.01589039,0.1141819,0.002129038,0.001986554,0.0005183924,0.002158813,0.001176431,0.2809516,0.0002167276,0.00305536,0.1126827],"study_design_scores_gemma":[0.04748762,0.3511297,0.5766567,0.0001131339,0.002528366,0.001252665,0.0006745185,0.0020287,0.01250891,0.0001847997,0.005318959,0.0001159826],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985647,0.0007054266,0.0001150898,0.00002920666,0.00001036619,0.0001145938,0.0001355529,0.000006385155,0.0003186794],"genre_scores_gemma":[0.9982419,0.0004251671,0.0003001815,0.0001631679,0.00002643433,0.0001966139,0.0002128658,0.000004676244,0.0004290061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001336903,"threshold_uncertainty_score":0.004472375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0855138984506186,"score_gpt":0.4492437812063357,"score_spread":0.363729882755717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}