{"id":"W4388627467","doi":"10.25251/skin.7.supp.251","title":"Investigator- and Patient-Rated Local Tolerability in Phase 3 Trials of Topical Roflumilast in Patients With Psoriasis, Seborrheic Dermatitis, and Atopic Dermatitis","year":2023,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dermatrials Research; Probity Medical Research; Queen's University","funders":"","keywords":"Roflumilast; Tolerability; Dermatology; Seborrheic dermatitis; Medicine; Atopic dermatitis; Psoriasis; Apremilast; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007987315,0.0009343134,0.002122636,0.000511216,0.0004808762,0.0009471555,0.0004612797,0.0009999798,0.00309984],"category_scores_gemma":[0.005219472,0.0004166442,0.003252989,0.000689466,0.0004102407,0.0008872029,0.0002954666,0.001886668,0.0003286256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005425264,"about_ca_system_score_gemma":0.0007726755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000614087,"about_ca_topic_score_gemma":0.001982892,"domain_scores_codex":[0.9966403,0.002174075,0.0003913101,0.0002112017,0.0003429061,0.0002401395],"domain_scores_gemma":[0.9975302,0.001020186,0.0007860935,0.0001096747,0.0002894263,0.0002644526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7043692,0.01270663,0.01622823,0.006772511,0.01024585,0.0002875754,0.0007193394,0.002235728,0.03085727,0.0003442398,0.006009667,0.2092238],"study_design_scores_gemma":[0.5275262,0.3495313,0.100789,0.0006757964,0.004278189,0.000770031,0.0003320544,0.001508725,0.005069399,0.0004554189,0.008923483,0.0001403563],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9492018,0.0340718,0.001737222,0.0007743236,0.0002502526,0.005644136,0.002419571,0.0001806875,0.005720192],"genre_scores_gemma":[0.9844719,0.006933778,0.001856042,0.0007297001,0.0001645408,0.003215781,0.001254213,0.00003132237,0.001342771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007987315,"threshold_uncertainty_score":0.04224151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0142335968268544,"score_gpt":0.2521682519196282,"score_spread":0.2379346550927738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}