{"id":"W4388627525","doi":"10.25251/skin.7.supp.283","title":"Tapinarof Cream 1% Once Daily: Significant Efficacy in the Treatment of Atopic Dermatitis in Two Pivotal Phase 3 Trials in Adults and Children Down to 2 Years of Age","year":2023,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; University of Toronto; Innovaderm (Canada)","funders":"Sanofi Genzyme; Allergan; Genentech; Merz Pharmaceuticals; Galderma; Astellas Pharma; Coherus Biosciences; Glenmark Pharmaceuticals; Castle Biosciences; Pfizer; Biogen; Incyte; Boston Pharmaceuticals; Sun Pharma; Dermira; Les Laboratories Pierre Fabre; DUSA Pharmaceuticals; Meiji Seika Pharma; Kiniksa Pharmaceuticals; Baxalta; Novartis; Celgene; Ablynx; LEO Pharma; Ortho Dermatologics; Gilead Sciences; GlaxoSmithKline; Astellas Pharma US; Amgen; Eli Lilly and Company; Bristol-Myers Squibb; UCB Pharma; Valeant Pharmaceuticals International; Bausch Health; Bayer HealthCare; L'Oreal USA; Sanofi; Regeneron Pharmaceuticals; Abbott Laboratories","keywords":"Atopic dermatitis; Medicine; Pediatrics; Dermatology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001936464,0.001229966,0.002365466,0.0003848198,0.0003566495,0.001149384,0.0006540788,0.001338789,0.00373613],"category_scores_gemma":[0.001156063,0.0004234498,0.001976939,0.0003631616,0.0007097252,0.0008523132,0.0002562631,0.002999769,0.0004885058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005807462,"about_ca_system_score_gemma":0.0008191742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001254918,"about_ca_topic_score_gemma":0.004415287,"domain_scores_codex":[0.9996244,0.000149821,0.00002321532,0.00006519783,0.00004207265,0.00009532205],"domain_scores_gemma":[0.9992949,0.0002722719,0.0001136144,0.00003366763,0.00005932404,0.000226157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7317171,0.01984855,0.004654875,0.004609607,0.002970566,0.0005988699,0.0006824909,0.001207713,0.04231561,0.0005963477,0.006736923,0.1840614],"study_design_scores_gemma":[0.7340138,0.234966,0.01837667,0.0003055434,0.00131536,0.0006451597,0.0001858499,0.000644444,0.003527164,0.0003186948,0.005638115,0.00006314994],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627924,0.02912897,0.0008089748,0.001096311,0.0004208068,0.00147163,0.001437198,0.0001665186,0.002677385],"genre_scores_gemma":[0.9735997,0.0180851,0.001784159,0.001286735,0.0003177666,0.0008084265,0.001653146,0.00005445219,0.002410504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00373613,"threshold_uncertainty_score":0.01249862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02112784819323222,"score_gpt":0.3429666336027493,"score_spread":0.3218387854095171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}