{"id":"W4388627555","doi":"10.3389/fonc.2023.1272883","title":"Extracellular vesicle small RNA cargo discriminates non-cancer donors from pediatric B-lymphoblastic leukemia patients","year":2023,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton; Beatrice Hunter Cancer Research Institute; Atlantic Cancer Research Institute; Memorial University of Newfoundland","funders":"Janeway Children's Hospital Foundation; Children's Hospital Foundation; Memorial University of Newfoundland; BC Children's Hospital; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Lymphoblast; Bone marrow; Microvesicles; RNA; microRNA; Extracellular vesicles; Messenger RNA; Extracellular vesicle; Leukemia; Cancer research; Liquid biopsy; Biology; Cancer; Gene; Cancer cell; Medicine; Molecular biology; Immunology; Cell culture; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000212059,0.000196497,0.0002922436,0.0004986794,0.0002516857,0.0005753697,0.0001723609,0.0002919729,0.001560102],"category_scores_gemma":[0.0007469598,0.0001075838,0.0001431693,0.0004339807,0.0001816,0.0002439382,0.0003364038,0.0003077255,0.0004113543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002363185,"about_ca_system_score_gemma":0.0001489464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007741753,"about_ca_topic_score_gemma":0.0006970007,"domain_scores_codex":[0.9997879,0.00003613808,0.00002886399,0.00006113222,0.00004080289,0.00004524439],"domain_scores_gemma":[0.9997826,0.00004014025,0.00008497992,0.00001332826,0.00002353792,0.00005544709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001120197,0.00009134656,0.9686641,0.00006212907,0.00003347919,0.001066727,0.0004001741,0.00008247785,0.01473773,0.0002248385,0.0004598199,0.01305706],"study_design_scores_gemma":[0.00003783053,0.0006386533,0.976671,0.00003361702,0.00007176837,0.01007017,0.001086156,0.0004387029,0.005911443,0.0002195507,0.004805312,0.00001572512],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983254,0.0004956845,0.0001851024,0.00003761599,0.000008460302,0.00001305794,0.0002525061,0.000007505298,0.0006746888],"genre_scores_gemma":[0.9989111,0.0002286133,0.0001654252,0.00005971133,0.000009419185,0.0000162193,0.0004165463,0.000005549105,0.0001873723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001560102,"threshold_uncertainty_score":0.005219042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009209424944821958,"score_gpt":0.246026699327821,"score_spread":0.2368172743829991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}