{"id":"W4388627555","doi":"10.3389/fonc.2023.1272883","title":"Extracellular vesicle small RNA cargo discriminates non-cancer donors from pediatric B-lymphoblastic leukemia patients","year":2023,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton; Beatrice Hunter Cancer Research Institute; Atlantic Cancer Research Institute; Memorial University of Newfoundland","funders":"Janeway Children's Hospital Foundation; Children's Hospital Foundation; Memorial University of Newfoundland; BC Children's Hospital; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Lymphoblast; Bone marrow; Microvesicles; RNA; microRNA; Extracellular vesicles; Messenger RNA; Extracellular vesicle; Leukemia; Cancer research; Liquid biopsy; Biology; Cancer; Gene; Cancer cell; Medicine; Molecular biology; Immunology; Cell culture; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002360845,0.0003346219,0.0004062954,0.0002471244,0.0001023444,0.00002618431,0.0005934335,0.000463585,0.00004526388],"category_scores_gemma":[0.0002198549,0.0003598189,0.000162419,0.0004534545,0.00017854,0.00001208022,0.0003425233,0.0002401871,0.00009200038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005318443,"about_ca_system_score_gemma":0.0004815737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002842097,"about_ca_topic_score_gemma":0.0001820199,"domain_scores_codex":[0.9975817,0.0001854019,0.0005023821,0.0008191129,0.0001943975,0.0007170694],"domain_scores_gemma":[0.9988628,0.00006539009,0.000206238,0.0005534318,0.00008010487,0.0002320108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005859729,0.0004897316,0.7792791,0.00009463951,0.0001462786,0.0002278824,0.0004880689,0.002063795,0.1125348,0.00001935003,0.07608905,0.02798139],"study_design_scores_gemma":[0.01386388,0.0018106,0.7603981,0.0001009708,0.0006999855,0.000005221779,0.002146297,0.01271834,0.1372858,0.00291416,0.06549927,0.002557303],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869012,0.006737456,0.002433515,0.00008897898,0.002750489,0.0004057472,0.0001417821,0.00005221351,0.0004886481],"genre_scores_gemma":[0.991132,0.002451221,0.003189038,0.000143615,0.0007183428,0.0001998264,0.000699766,0.00008759116,0.001378579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02542409,"threshold_uncertainty_score":0.9998854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009209424944821958,"score_gpt":0.246026699327821,"score_spread":0.2368172743829991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}