{"id":"W4388627894","doi":"10.1167/iovs.64.14.14","title":"Cross-Platform Identification and Validation of Uveal Melanoma Vitreous Protein Biomarkers","year":2023,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Eye Institute; Canadian Institutes of Health Research; National Institutes of Health; Research to Prevent Blindness","keywords":"Fold change; Proteomics; S100A8; Multiplex; Melanoma; Epiretinal membrane; Vitrectomy; Biomarker; Gene expression; Ocular Melanoma; Medicine; Pathology; Chemistry; Molecular biology; Cancer research; Gene; Ophthalmology; Biology; Bioinformatics; Visual acuity; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001116042,0.0005745761,0.0005688968,0.001219655,0.0004091074,0.0008930473,0.0003279315,0.0005385138,0.0009608649],"category_scores_gemma":[0.001609018,0.0001916006,0.0003754534,0.0006025657,0.0003067597,0.000296628,0.0007683654,0.0004433615,0.0005538004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003196653,"about_ca_system_score_gemma":0.0003726153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006247647,"about_ca_topic_score_gemma":0.00089221,"domain_scores_codex":[0.9990289,0.0001577992,0.00007942998,0.0003459959,0.0003083829,0.00007948099],"domain_scores_gemma":[0.9991731,0.0001418999,0.0002538241,0.00009904853,0.0002581942,0.00007381758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001586182,0.0003766399,0.1441698,0.0003448905,0.0003366064,0.0004565066,0.0001720799,0.0006462452,0.819413,0.0001205989,0.0004806592,0.0318968],"study_design_scores_gemma":[0.0001303272,0.002458689,0.409104,0.000129302,0.0006424637,0.005992742,0.00049723,0.01315208,0.5609781,0.0003354118,0.006528662,0.00005110769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910365,0.003175727,0.003994208,0.00007624031,0.00004802358,0.0001072492,0.0007630007,0.00009687495,0.0007022613],"genre_scores_gemma":[0.9874199,0.0008034226,0.009028231,0.0001667213,0.00003690907,0.0001004805,0.001737607,0.00002747452,0.0006791593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001219655,"threshold_uncertainty_score":0.005902231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04992065895941639,"score_gpt":0.380436263764856,"score_spread":0.3305156048054396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}