{"id":"W4388627894","doi":"10.1167/iovs.64.14.14","title":"Cross-Platform Identification and Validation of Uveal Melanoma Vitreous Protein Biomarkers","year":2023,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Eye Institute; Canadian Institutes of Health Research; National Institutes of Health; Research to Prevent Blindness","keywords":"Fold change; Proteomics; S100A8; Multiplex; Melanoma; Epiretinal membrane; Vitrectomy; Biomarker; Gene expression; Ocular Melanoma; Medicine; Pathology; Chemistry; Molecular biology; Cancer research; Gene; Ophthalmology; Biology; Bioinformatics; Visual acuity; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0008464474,0.0001272025,0.000221959,0.0003040525,0.0002644622,0.00002267969,0.0001205485,0.0001229202,0.00004535332],"category_scores_gemma":[0.0006099087,0.0001087037,0.000035571,0.001139345,0.004494037,0.00031467,0.00009909275,0.0001017495,0.00007947834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008567494,"about_ca_system_score_gemma":0.0002871912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005593876,"about_ca_topic_score_gemma":7.461809e-7,"domain_scores_codex":[0.9986424,0.00006728047,0.000287571,0.0004330702,0.0002926519,0.0002770109],"domain_scores_gemma":[0.9991717,0.00008520472,0.0001970538,0.000173477,0.0002009018,0.0001716583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000601329,0.00007046957,0.3447621,0.00002379509,0.00003870383,0.0001566834,0.00030255,0.00000137434,0.6539038,0.00008205424,0.000003848123,0.0005945084],"study_design_scores_gemma":[0.00039493,0.0005722915,0.4836947,0.00002343643,0.00002258219,0.0002119136,0.0000751301,0.0001265282,0.5129476,0.001878159,0.00000317315,0.000049591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982817,0.00002776832,0.000001727352,0.0003073067,0.0001188325,0.0005425807,0.000009076383,0.0000458803,0.00066511],"genre_scores_gemma":[0.9989753,0.000002098217,0.000443238,0.00002431897,0.00001685541,0.00005602122,0.00004011993,0.000008300689,0.0004336816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1409563,"threshold_uncertainty_score":0.9982151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04992065895941639,"score_gpt":0.380436263764856,"score_spread":0.3305156048054396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}