{"id":"W4388632779","doi":"10.3389/fimmu.2023.1271209","title":"Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron","year":2023,"lang":"en","type":"letter","venue":"Frontiers in Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Universidad Nacional de La Plata; Consejo Nacional de Investigaciones Científicas y Técnicas","keywords":"Heterologous; Vaccination; Booster dose; Booster (rocketry); Adjuvant; Virology; Vaccination schedule; Regimen; Immune system; Biology; Immunology; Medicine; Immunization; Gene; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081823,0.0002958367,0.0003606818,0.0001138478,0.00006885296,0.0001691414,0.0002328955,0.0002474949,0.0006242638],"category_scores_gemma":[0.00007609812,0.00006709493,0.0002075828,0.00009233745,0.0001674947,0.0001867653,0.00008044315,0.0004928119,0.000134924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001909739,"about_ca_system_score_gemma":0.0002136466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005511564,"about_ca_topic_score_gemma":0.001090307,"domain_scores_codex":[0.9999295,0.00001017424,0.00000388326,0.00001803499,0.00002279447,0.00001557524],"domain_scores_gemma":[0.9999551,0.000006708627,0.00001642547,0.000004376775,0.000006116015,0.00001128928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0004285158,0.0004269459,0.0002228887,0.00008996547,0.00001123234,0.0000317801,0.00001680748,0.0002066381,0.9925097,0.00004080498,0.00005681042,0.005957801],"study_design_scores_gemma":[0.0002323797,0.02999449,0.006731254,0.00001921348,0.00008989305,0.0004021503,0.00005185413,0.001844715,0.9569552,0.00004442341,0.003623067,0.00001130959],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975944,0.0008002833,0.001086981,0.00003447534,0.00003260426,0.00003725658,0.00004746743,0.00002169097,0.000344923],"genre_scores_gemma":[0.9958163,0.000918678,0.002177414,0.00005155909,0.00002880683,0.00002872406,0.0002041957,0.000007928929,0.000766389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006242638,"threshold_uncertainty_score":0.002088368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0189452479154221,"score_gpt":0.2817431301108848,"score_spread":0.2627978821954626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}