{"id":"W4388636018","doi":"10.3390/metabo13111142","title":"Metabolomics Analysis of Mesenchymal Stem Cell (MSC) Therapy in a Phase I Clinical Trial of Septic Shock: An Exploratory Study","year":2023,"lang":"en","type":"article","venue":"Metabolites","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto; Ottawa Hospital; University of Ottawa; St. Michael's Hospital; University of Calgary","funders":"Groupe canadien de recherche en soins intensifs; Canadian Institutes of Health Research; University of Ottawa; University of Calgary; Alberta Health Services","keywords":"Metabolomics; Septic shock; Medicine; Mesenchymal stem cell; Sepsis; Clinical trial; Metabolome; Intensive care medicine; Randomized controlled trial; Internal medicine; Bioinformatics; Metabolite; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003506969,0.001406413,0.00245575,0.000421215,0.0004336612,0.0009978423,0.0004787452,0.001186148,0.001663094],"category_scores_gemma":[0.002289326,0.0003825961,0.001768765,0.0004922933,0.000871842,0.000544714,0.0005361974,0.001650482,0.0003925057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004936574,"about_ca_system_score_gemma":0.001452007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002068615,"about_ca_topic_score_gemma":0.0003100664,"domain_scores_codex":[0.9988934,0.0006681008,0.00005792839,0.000123722,0.0001145726,0.0001422866],"domain_scores_gemma":[0.9986425,0.0003154045,0.0002885203,0.0001729806,0.0001780238,0.0004025588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6589704,0.08034803,0.009473086,0.0009724068,0.002646455,0.0004849639,0.0003723063,0.004412025,0.193563,0.0004046168,0.001644632,0.04670801],"study_design_scores_gemma":[0.08899312,0.8775885,0.01407804,0.00003054268,0.00100364,0.0001691302,0.00009327324,0.0013818,0.01457392,0.0002503984,0.001791932,0.00004570906],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928697,0.0008032114,0.001581813,0.0003133463,0.00008408849,0.003086552,0.0006393269,0.00004711034,0.0005750048],"genre_scores_gemma":[0.9842961,0.0009780487,0.003966223,0.0008528958,0.000182754,0.007103428,0.001311236,0.0000247989,0.001284514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003506969,"threshold_uncertainty_score":0.01854688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06956488512650984,"score_gpt":0.3752945419432447,"score_spread":0.3057296568167349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}