{"id":"W4388636018","doi":"10.3390/metabo13111142","title":"Metabolomics Analysis of Mesenchymal Stem Cell (MSC) Therapy in a Phase I Clinical Trial of Septic Shock: An Exploratory Study","year":2023,"lang":"en","type":"article","venue":"Metabolites","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto; Ottawa Hospital; University of Ottawa; St. Michael's Hospital; University of Calgary","funders":"Groupe canadien de recherche en soins intensifs; Canadian Institutes of Health Research; University of Ottawa; University of Calgary; Alberta Health Services","keywords":"Metabolomics; Septic shock; Medicine; Mesenchymal stem cell; Sepsis; Clinical trial; Metabolome; Intensive care medicine; Randomized controlled trial; Internal medicine; Bioinformatics; Metabolite; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002719284,0.0002769029,0.001431395,0.0007846429,0.0000430796,0.0000157709,0.0003898573,0.0001541637,0.00002883216],"category_scores_gemma":[0.0001460895,0.0002343065,0.0005491606,0.002119505,0.000139655,0.00001298084,0.0001956218,0.0001421568,0.000002807041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005849192,"about_ca_system_score_gemma":0.0001064449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002330138,"about_ca_topic_score_gemma":0.0001468039,"domain_scores_codex":[0.9966927,0.0007501771,0.001259436,0.0006316497,0.0003122332,0.0003538349],"domain_scores_gemma":[0.9983293,0.0001191781,0.0004416823,0.0008295873,0.0001753736,0.0001048887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01293347,0.009409509,0.08595811,0.00002920461,0.00554846,0.000010628,0.002038796,0.0002268693,0.8742781,0.0002852224,0.0001147439,0.009166924],"study_design_scores_gemma":[0.1353918,0.01727065,0.07981667,0.000008287064,0.004943979,6.963416e-7,0.01857987,0.001827496,0.731735,0.0001803394,0.009125261,0.001119921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942188,0.00449222,0.00004318279,0.00001292067,0.0003113993,0.0006788436,0.0001259008,0.00001730212,0.00009947036],"genre_scores_gemma":[0.9943226,0.004865588,0.0002338204,0.00002972761,0.0001637308,0.00008591802,0.0001206488,0.00002918782,0.0001487801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.142543,"threshold_uncertainty_score":0.955474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06956488512650984,"score_gpt":0.3752945419432447,"score_spread":0.3057296568167349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}