{"id":"W4388637594","doi":"10.3390/jcm12227045","title":"Protein Biomarkers Shared by Multiple Neurodegenerative Diseases Are Calmodulin-Binding Proteins Offering Novel and Potentially Universal Therapeutic Targets","year":2023,"lang":"en","type":"review","venue":"Journal of Clinical Medicine","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Calmodulin; Amyotrophic lateral sclerosis; Medicine; Calcium-binding protein; Disease; Biomarker; Dementia; Frontotemporal dementia; Cell biology; Neuroscience; Biology; Calcium; Biochemistry; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002212923,0.0003289131,0.0005543293,0.0003053262,0.0002623899,0.0006380411,0.0002714423,0.0005676575,0.001257055],"category_scores_gemma":[0.000144175,0.0001082234,0.0002664441,0.0002411295,0.0003908674,0.0003667413,0.0004649116,0.0009577696,0.0003030292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003949555,"about_ca_system_score_gemma":0.0003759782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003518983,"about_ca_topic_score_gemma":0.0009837872,"domain_scores_codex":[0.999893,0.00002118521,0.000008997696,0.00002658564,0.00003144634,0.00001884338],"domain_scores_gemma":[0.9999262,0.00001099448,0.00002264638,0.000005554448,0.00001571802,0.00001881549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000926365,0.0003864856,0.004434878,0.001803438,0.0001762122,0.001114221,0.0001715963,0.0003273586,0.7297108,0.0105547,0.006996549,0.2433975],"study_design_scores_gemma":[0.0008460314,0.003792796,0.03855573,0.0006234943,0.0007167874,0.01147122,0.0002871788,0.004147939,0.4269027,0.01268675,0.4998954,0.00007404605],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2587306,0.6777281,0.02511276,0.01168077,0.001363197,0.0002620167,0.0004259936,0.0005634099,0.02413307],"genre_scores_gemma":[0.813754,0.1594788,0.01624463,0.00199935,0.001113291,0.0001371574,0.0003156354,0.00002508417,0.00693202],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001257055,"threshold_uncertainty_score":0.004205287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1317863072844222,"score_gpt":0.3983698659373764,"score_spread":0.2665835586529541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}