{"id":"W4388646345","doi":"10.1002/jgm.3627","title":"Enhancement of adeno‐associated virus serotype 6 transduction into T cells with cell‐penetrating peptides","year":2023,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canada Research Chairs; Faculty of Engineering, McGill University","keywords":"Transduction (biophysics); Jurkat cells; Biology; Viral vector; Transgene; Cell culture; Cell biology; Gene delivery; Multiplicity of infection; Potato virus X; Molecular biology; Virology; T cell; Virus; Transfection; Immune system; Immunology; Gene; Biochemistry; Genetics; Plant virus; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002254817,0.0004282901,0.0002014289,0.0001573671,0.00007956489,0.0002572477,0.0001369146,0.0002817715,0.0009145065],"category_scores_gemma":[0.0001302595,0.00008610832,0.000292369,0.0001249709,0.0001358959,0.0001891108,0.0001630976,0.0004590742,0.0002648025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001351607,"about_ca_system_score_gemma":0.00013959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000162655,"about_ca_topic_score_gemma":0.0001822873,"domain_scores_codex":[0.9998246,0.00004449656,0.00002006595,0.00002176435,0.00005229558,0.00003678857],"domain_scores_gemma":[0.9999014,0.00002688627,0.00002643483,0.000007089066,0.00001844361,0.00001960584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003196829,0.00002376115,0.00005187497,0.00004203188,0.000003416582,0.00002160677,0.000007914332,0.00006214195,0.9990929,0.00002479569,0.00001322467,0.0006244098],"study_design_scores_gemma":[0.000008840276,0.0005267445,0.000629624,0.000004254048,0.00001630405,0.0001109212,0.00000766522,0.000542568,0.9970803,0.0000123869,0.001057665,0.000002811421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920506,0.001521018,0.005045845,0.00006384265,0.00003444224,0.00006203885,0.0001285019,0.0000520035,0.001041716],"genre_scores_gemma":[0.9884176,0.001267165,0.008613336,0.00005433619,0.00002107676,0.00004084231,0.0002923793,0.00001718064,0.001276057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009145065,"threshold_uncertainty_score":0.003059328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01779368960079492,"score_gpt":0.2904554496241775,"score_spread":0.2726617600233825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}