{"id":"W4388660979","doi":"10.1111/tpj.16528","title":"Improved production of the antidiabetic metabolite montbretin A in <i>Nicotiana benthamiana</i>: discovery, characterization, and use of <i>Crocosmia</i> shikimate shunt genes","year":2023,"lang":"en","type":"article","venue":"The Plant Journal","topic":"Plant Gene Expression Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; Alexander von Humboldt-Stiftung","keywords":"Nicotiana benthamiana; Shikimate pathway; Phenylpropanoid; Biochemistry; Biology; Biosynthesis; Metabolic engineering; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002022833,0.0004802979,0.0003050705,0.0002076705,0.0002035731,0.0004441801,0.0003406336,0.0003319875,0.0003748351],"category_scores_gemma":[0.0001275457,0.0001692611,0.0003582565,0.0002415999,0.0001758006,0.0002637023,0.0003103882,0.0005720262,0.0002713157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005642825,"about_ca_system_score_gemma":0.0003350331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004066702,"about_ca_topic_score_gemma":0.006025915,"domain_scores_codex":[0.9998642,0.00001725676,0.00001526976,0.00003656452,0.00004306903,0.00002367364],"domain_scores_gemma":[0.9998637,0.00001609178,0.00003781153,0.00001662468,0.00002793258,0.00003788935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001155377,0.00001123786,0.00006386498,0.00001146193,0.000001787257,0.00001182399,0.000008694741,0.00003049207,0.9992781,0.00002670917,0.000006793268,0.0005374855],"study_design_scores_gemma":[0.000007896512,0.0001272123,0.002966627,0.000005926834,0.00002612793,0.00009837885,0.00003329093,0.001195051,0.9920334,0.00003251519,0.003465972,0.000007532778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849551,0.001438801,0.01062625,0.0001543128,0.00002921654,0.00008379924,0.0006619242,0.0002296738,0.001820923],"genre_scores_gemma":[0.979997,0.001346443,0.01226024,0.00008918531,0.000008333429,0.00004169577,0.002310477,0.00009887479,0.003847722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004066702,"threshold_uncertainty_score":0.008086085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161862118524742,"score_gpt":0.2131231438288625,"score_spread":0.2015045226436151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}