{"id":"W4388660979","doi":"10.1111/tpj.16528","title":"Improved production of the antidiabetic metabolite montbretin A in <i>Nicotiana benthamiana</i>: discovery, characterization, and use of <i>Crocosmia</i> shikimate shunt genes","year":2023,"lang":"en","type":"article","venue":"The Plant Journal","topic":"Plant Gene Expression Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; Alexander von Humboldt-Stiftung","keywords":"Nicotiana benthamiana; Shikimate pathway; Phenylpropanoid; Biochemistry; Biology; Biosynthesis; Metabolic engineering; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004980756,0.0001156535,0.0001985937,0.00009418967,0.00009148438,0.00004352224,0.0002199368,0.00005455587,0.000002175397],"category_scores_gemma":[0.0001142701,0.00006644517,0.00009009902,0.0002871414,0.00008657542,0.00002150982,0.0001497123,0.0001194591,4.669689e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005395022,"about_ca_system_score_gemma":0.0000527895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003755603,"about_ca_topic_score_gemma":0.00007440299,"domain_scores_codex":[0.9989169,0.0001961084,0.000364349,0.0001714648,0.0001719939,0.0001791709],"domain_scores_gemma":[0.9992481,0.00002469208,0.0003549216,0.0002757696,0.00005993075,0.00003654016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008230114,0.00002583068,0.01552795,0.00001864015,0.0000711031,0.00000137996,0.0001218042,0.0003059424,0.9827942,0.000006874857,0.0006010545,0.0004429038],"study_design_scores_gemma":[0.0002653344,0.00002840914,0.0899357,0.00006959291,0.00008142592,0.0000873425,0.00009277737,0.00127619,0.9045233,0.00001437758,0.003529966,0.0000956398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981406,0.0003508774,0.0001462431,0.0007338498,0.0001868336,0.0001579126,0.0002757913,0.000003583263,0.00000433308],"genre_scores_gemma":[0.9948282,0.004435701,0.00004485834,0.00008575919,0.00008728384,0.000005185464,0.0001230719,0.00001179986,0.0003781068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07827097,"threshold_uncertainty_score":0.2709556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161862118524742,"score_gpt":0.2131231438288625,"score_spread":0.2015045226436151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}