{"id":"W4388662516","doi":"10.1200/jco.22.02668","title":"Prediction of Adjuvant Gemcitabine Sensitivity in Resectable Pancreatic Adenocarcinoma Using the GemPred RNA Signature: An Ancillary Study of the PRODIGE-24/CCTG PA6 Clinical Trial","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia; Queen's University","funders":"National Cancer Institute","keywords":"Medicine; Gemcitabine; Internal medicine; Folinic acid; Hazard ratio; Oxaliplatin; Population; Oncology; Pancreatic cancer; Irinotecan; Adenocarcinoma; Adjuvant therapy; Gastroenterology; Cancer; Fluorouracil; Colorectal cancer; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002313981,0.0004591982,0.0006304416,0.0001453213,0.0001689299,0.0004967939,0.0002428486,0.0004015963,0.000565322],"category_scores_gemma":[0.00175724,0.000146251,0.0004783613,0.0001764816,0.000312471,0.0002744447,0.0002364783,0.0006447887,0.0001463478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003432859,"about_ca_system_score_gemma":0.0003613795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003685224,"about_ca_topic_score_gemma":0.0008739908,"domain_scores_codex":[0.9994005,0.0003939308,0.0000267807,0.00007706419,0.00006140063,0.00004040022],"domain_scores_gemma":[0.9991162,0.0003325173,0.0001992026,0.0001079641,0.00005359084,0.0001904414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4355674,0.005908939,0.3455836,0.0004171479,0.002274483,0.0005308043,0.0002946613,0.007549288,0.04515922,0.0002375835,0.002417427,0.1540594],"study_design_scores_gemma":[0.06496587,0.2329888,0.6292423,0.0001192518,0.002808735,0.00221054,0.0002401768,0.03149214,0.02693534,0.0007970255,0.008080057,0.0001196403],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990711,0.0003158813,0.0001193078,0.00004378058,0.000009990761,0.00005830052,0.0001599757,0.000005911297,0.0002157361],"genre_scores_gemma":[0.998447,0.0001321023,0.0003852075,0.00007219606,0.00002660645,0.00007012755,0.0007273813,0.000002766183,0.0001365798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002313981,"threshold_uncertainty_score":0.01223767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4055818638620657,"score_gpt":0.5186904279081003,"score_spread":0.1131085640460345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}