{"id":"W4388662575","doi":"10.1200/jco.23.00339","title":"Olaparib for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer and Alterations in <i>BRCA1</i> and/or <i>BRCA2</i> in the PROfound Trial","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Centre Hospitalier de l’Université de Montréal","funders":"Medical Research Council; National Institute for Health and Care Research; AstraZeneca","keywords":"Olaparib; Medicine; Prostate cancer; Oncology; Internal medicine; PARP inhibitor; Cancer; Clinical trial; Prostate; Gynecology; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007557566,0.0004680313,0.0008359429,0.0002001964,0.0001621215,0.0006684453,0.0003526236,0.0003444696,0.002176319],"category_scores_gemma":[0.0007515533,0.0001613634,0.0009408878,0.0002813919,0.0002569557,0.0004873872,0.0002940987,0.001602001,0.0002438842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003501365,"about_ca_system_score_gemma":0.0005379171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000388727,"about_ca_topic_score_gemma":0.001757638,"domain_scores_codex":[0.999823,0.00009195053,0.000009484471,0.0000243706,0.00002179807,0.00002935879],"domain_scores_gemma":[0.9997236,0.00006810685,0.00005784261,0.00001861824,0.00001493237,0.0001169221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5661174,0.004836978,0.0126034,0.001663086,0.003393694,0.00032176,0.000167086,0.00484885,0.01934715,0.001457796,0.01694514,0.3682976],"study_design_scores_gemma":[0.7070156,0.1788966,0.06307741,0.0005677592,0.003846129,0.001611911,0.0002025761,0.005271439,0.006037861,0.004469214,0.0288781,0.0001254002],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688167,0.01713087,0.0007851759,0.001459328,0.0003155476,0.0006726673,0.002865725,0.0001435825,0.0078104],"genre_scores_gemma":[0.9865636,0.005378884,0.001075427,0.001731914,0.0002150006,0.0003144695,0.002959963,0.00001815955,0.001742679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002176319,"threshold_uncertainty_score":0.007280469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.20027265815935,"score_gpt":0.501004182842899,"score_spread":0.300731524683549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}