{"id":"W4388663532","doi":"10.2139/ssrn.4631547","title":"On-Target, Dual Aminopeptidase Inhibition Provides Cross-Species Antimalarial Activity","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Discovery Centre","funders":"","keywords":"Aminopeptidase; Dual (grammatical number); Antimalarial Agent; Malaria; Chemistry; Plasmodium falciparum; Pharmacology; Computational biology; Biology; Biochemistry; Leucine; Amino acid; Immunology; Art","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002332564,0.0005830373,0.0005597275,0.0003012585,0.00009408039,0.000623083,0.0002747453,0.0004470079,0.004168924],"category_scores_gemma":[0.0002206051,0.0001703758,0.0003259898,0.0002092529,0.0001862142,0.0002658777,0.000266455,0.0007668845,0.001134975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002892292,"about_ca_system_score_gemma":0.0001502684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001864848,"about_ca_topic_score_gemma":0.000250151,"domain_scores_codex":[0.9998067,0.00002661211,0.00001142311,0.00004355635,0.0000718083,0.00003994844],"domain_scores_gemma":[0.9998999,0.00001470108,0.00003439021,0.00001534209,0.00001778862,0.00001793019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004805315,0.00004814204,0.0001849215,0.00006086862,0.00002867987,0.00004761495,0.000003852364,0.0001795049,0.9885289,0.0003457695,0.0002360218,0.009855158],"study_design_scores_gemma":[0.00002315489,0.0004213365,0.001634282,0.00000379913,0.00003339352,0.0003872325,0.000005007712,0.002873467,0.9913207,0.0002173844,0.00307547,0.000004690494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9290614,0.007031359,0.04023307,0.0005226336,0.0002371857,0.00009480288,0.001789724,0.0007591644,0.02027067],"genre_scores_gemma":[0.9784929,0.001656791,0.01002477,0.0001500448,0.00004106513,0.00002342294,0.0008943303,0.00008244482,0.008634209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004168924,"threshold_uncertainty_score":0.01394647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02814819357179552,"score_gpt":0.3061762945036831,"score_spread":0.2780281009318876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}