{"id":"W4388671384","doi":"10.1101/2023.11.08.566338","title":"Endothelial stiffening induced by CD36-mediated lipid uptake leads to endothelial barrier disruption and contributes to atherosclerotic lesions","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"CD36; Downregulation and upregulation; Endothelium; Endothelial dysfunction; Stiffening; Internal medicine; Endothelial stem cell; Endocrinology; Biology; Chemistry; Medicine; In vitro; Biochemistry; Materials science; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724283,0.0003368878,0.0003185864,0.0003075718,0.0002062535,0.000310229,0.0001499549,0.0004069256,0.002298292],"category_scores_gemma":[0.0001115888,0.000205178,0.0002837405,0.0001679383,0.0002086961,0.0001937766,0.0002779099,0.0008160531,0.0004205921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474392,"about_ca_system_score_gemma":0.0001392134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000411322,"about_ca_topic_score_gemma":0.0007049395,"domain_scores_codex":[0.9998125,0.00002459829,0.00002117583,0.00004747254,0.00004486931,0.00004942491],"domain_scores_gemma":[0.9997371,0.00001482833,0.000109687,0.00002662599,0.00002537692,0.00008644241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001744878,0.00003190881,0.0003311935,0.00002670524,0.000005099701,0.00005308864,0.000008237045,0.00001147063,0.9989061,0.00003620189,0.00002054304,0.0003949164],"study_design_scores_gemma":[0.00004735023,0.0009795751,0.0531223,0.00002529955,0.00006934829,0.001125795,0.0000928761,0.0008535812,0.9412913,0.0001076859,0.002273276,0.00001164452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951816,0.00110114,0.002504974,0.0001362474,0.00002602521,0.00002179738,0.0003301961,0.0000623251,0.0006357282],"genre_scores_gemma":[0.9932218,0.0009295766,0.001748687,0.0001105238,0.00001987845,0.0000388765,0.0003080305,0.00001718549,0.003605484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002298292,"threshold_uncertainty_score":0.007688582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02050471082894565,"score_gpt":0.2282683629442719,"score_spread":0.2077636521153263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}