{"id":"W4388671811","doi":"10.15252/embr.202357972","title":"MAPL loss dysregulates bile and liver metabolism in mice","year":2023,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; University of Ottawa; Montreal Neurological Institute and Hospital; University of Toronto; University Health Network; McGill University; Princess Margaret Cancer Centre","funders":"Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö; Canada Research Chairs; Government of Canada; McGill University","keywords":"Ubiquitin ligase; Cell biology; Knockout mouse; Bile acid; Biology; Lithocholic acid; Ubiquitin; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002816149,0.001184234,0.0005480753,0.002042143,0.0004024206,0.001283305,0.0006898731,0.001135649,0.00437589],"category_scores_gemma":[0.0002852934,0.0007405755,0.0006441352,0.00050439,0.001226295,0.0006166326,0.0007366426,0.001871224,0.001749356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007972095,"about_ca_system_score_gemma":0.0004036495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008771974,"about_ca_topic_score_gemma":0.001706111,"domain_scores_codex":[0.9993831,0.00005331058,0.00005443566,0.0001810567,0.0001720659,0.0001560574],"domain_scores_gemma":[0.9992647,0.00006143744,0.000349761,0.00005861144,0.00003656641,0.0002289943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006922475,0.0000935862,0.0004620661,0.0000654316,0.00002616229,0.000418536,0.00003710824,0.000129148,0.9955449,0.0004225218,0.000206494,0.001901838],"study_design_scores_gemma":[0.0001636869,0.0003661934,0.009594633,0.00003282475,0.0001453418,0.001155353,0.0002197329,0.001280746,0.9802972,0.0003545973,0.006361703,0.00002790486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812374,0.002426757,0.006324429,0.0009471036,0.0002332369,0.0000523661,0.003123775,0.001317207,0.004337656],"genre_scores_gemma":[0.9749542,0.001709453,0.003266522,0.0004365804,0.00009065194,0.0001339326,0.002079103,0.0005025518,0.01682708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00437589,"threshold_uncertainty_score":0.01463884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007080254452356166,"score_gpt":0.2316546699112985,"score_spread":0.2245744154589423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}