{"id":"W4388671811","doi":"10.15252/embr.202357972","title":"MAPL loss dysregulates bile and liver metabolism in mice","year":2023,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; University of Ottawa; Montreal Neurological Institute and Hospital; University of Toronto; University Health Network; McGill University; Princess Margaret Cancer Centre","funders":"Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö; Canada Research Chairs; Government of Canada; McGill University","keywords":"Ubiquitin ligase; Cell biology; Knockout mouse; Bile acid; Biology; Lithocholic acid; Ubiquitin; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002404753,0.000139106,0.000159193,0.00009606472,0.00004205291,0.00002274544,0.00006100414,0.0001620227,0.00004376601],"category_scores_gemma":[0.00009701425,0.0001293929,0.00004412284,0.0002219288,0.00006592512,0.000006616055,0.0001410693,0.0000881328,0.00001876698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009581705,"about_ca_system_score_gemma":0.00004549081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004812467,"about_ca_topic_score_gemma":0.00002372755,"domain_scores_codex":[0.9989544,0.0000420304,0.0002326575,0.0004084325,0.0001091403,0.0002533025],"domain_scores_gemma":[0.9995409,0.00000895454,0.00008426685,0.0002492272,0.00003738817,0.00007922391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001940242,0.00002921752,0.02553941,0.00001996663,0.00003795035,0.000425001,0.0001129318,0.00002932429,0.96838,0.00001115438,0.004132943,0.001262753],"study_design_scores_gemma":[0.000184291,0.00002683757,0.02469122,0.0000127028,0.000008944417,0.0003052749,0.00004510867,0.00003085539,0.9163629,0.0001525863,0.05798647,0.0001927768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971368,0.001746096,0.00000642038,0.0001149124,0.0002849845,0.0001414096,0.000005004239,0.00004037864,0.0005240171],"genre_scores_gemma":[0.997417,0.0005206798,0.0001114217,0.00009048634,0.000155368,0.00002991111,0.00008311305,0.00002628723,0.001565715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05385353,"threshold_uncertainty_score":0.527649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007080254452356166,"score_gpt":0.2316546699112985,"score_spread":0.2245744154589423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}