{"id":"W4388674869","doi":"10.1038/s41598-023-49129-7","title":"Network dynamical stability analysis reveals key “mallostatic” natural variables that erode homeostasis and drive age-related decline of health","year":2023,"lang":"en","type":"preprint","venue":"Scientific Reports","topic":"Mental Health Research Topics","field":"Psychology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; National Institute for Health and Care Research; Government of the United Kingdom","keywords":"Key (lock); Homeostasis; Biology; Medicine; Gerontology; Ecology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.02215155,0.0004768473,0.00182542,0.0008100156,0.0005182602,0.0002843638,0.000542598,0.0005309918,0.000798325],"category_scores_gemma":[0.001003324,0.0004431166,0.0003946901,0.002545705,0.001292608,0.0000904569,0.002063731,0.001324922,0.00001743029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005302367,"about_ca_system_score_gemma":0.0007932467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003865079,"about_ca_topic_score_gemma":0.00313822,"domain_scores_codex":[0.9886884,0.002348502,0.00303277,0.002792166,0.001748535,0.001389618],"domain_scores_gemma":[0.9923155,0.0008664739,0.002543238,0.003250177,0.0004535067,0.0005711318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004638337,0.001685548,0.830842,0.007962394,0.007789445,0.00431756,0.0181131,0.00425227,0.0002349401,0.003735666,0.08944122,0.03116201],"study_design_scores_gemma":[0.0007410799,0.0002486635,0.6595574,0.001039676,0.001013962,0.0001243708,0.001533665,0.006345913,0.00007065729,0.3263921,0.001846777,0.00108569],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676782,0.006620287,0.001142873,0.002415124,0.01845087,0.002676403,0.0003341375,0.0001938318,0.0004882782],"genre_scores_gemma":[0.9866546,0.0002146987,0.004552174,0.0001010406,0.00007427692,0.0001322274,0.003325839,0.00005926664,0.004885844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3226565,"threshold_uncertainty_score":0.9998021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1055658485844162,"score_gpt":0.409335545422627,"score_spread":0.3037696968382108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}