{"id":"W4388682025","doi":"10.1101/2023.11.13.566858","title":"Chemical Tools for the Gid4 Subunit of the Human E3 Ligase C-terminal to LisH (CTLH) Degradation Complex","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Genome Canada; Genentech; Bayer; Bristol-Myers Squibb","keywords":"Ubiquitin ligase; Linker; DNA ligase; Chemical library; Chemistry; Protein subunit; Computational biology; Computer science; Combinatorial chemistry; Ubiquitin; Small molecule; Biology; Biochemistry; DNA; Operating system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003459483,0.0004276757,0.0002525871,0.0003436427,0.0001931981,0.0002585371,0.0003488616,0.0003342136,0.002161344],"category_scores_gemma":[0.0002772916,0.0001766333,0.0002480113,0.0001896214,0.0003162119,0.0001812462,0.0003127258,0.0005528039,0.0008674642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007107134,"about_ca_system_score_gemma":0.0003410087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005886609,"about_ca_topic_score_gemma":0.0008435827,"domain_scores_codex":[0.9997364,0.00007039861,0.00001613808,0.00003796674,0.0000940637,0.00004509534],"domain_scores_gemma":[0.9998435,0.0000403278,0.00003519795,0.00002201229,0.00002252401,0.00003650561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008613736,0.00003957429,0.0001494768,0.00005378307,0.000005381306,0.00008709596,0.00001709575,0.0006171901,0.9955186,0.000420371,0.0001871372,0.002818211],"study_design_scores_gemma":[0.00001178545,0.0001694457,0.0001708125,0.000002040385,0.000003856499,0.0001166989,0.000008207918,0.0005644296,0.9960139,0.0000356501,0.002899724,0.00000352721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9203089,0.002941251,0.06713036,0.001009405,0.00009693181,0.0003026181,0.001290716,0.0007035841,0.006216102],"genre_scores_gemma":[0.9363325,0.001141738,0.049646,0.0002615514,0.00002138209,0.000171891,0.00160814,0.00009526042,0.0107215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002161344,"threshold_uncertainty_score":0.007230461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0446323736855223,"score_gpt":0.2694731273884601,"score_spread":0.2248407537029378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}