{"id":"W4388682052","doi":"10.1016/j.isci.2023.108473","title":"Gene-metabolite annotation with shortest reactional distance enhances metabolite genome-wide association studies results","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Institute of Nutrition, Metabolism and Diabetes; Government of Canada; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; Institut de Cardiologie de Montréal; Crohn's and Colitis Canada; Institute of Infection and Immunity; Institute of Genetics; Institut de Valorisation des Données; Fondation Institut de Cardiologie de Montréal; Zafgen; Ministère de l'Enseignement Supérieur, de la Recherche, de la Science et de la Technologie; National Institutes of Health; Canada Research Chairs; Novartis; Génome Québec; Genome British Columbia; Soy Nutrition Institute; Doris Duke Charitable Foundation; Genome Canada","keywords":"Metabolite; Annotation; Computational biology; KEGG; Metric (unit); Genetic association; Genome; Metabolomics; Computer science; Genome-wide association study; Biology; Bioinformatics; Gene; Genetics; Gene ontology; Single-nucleotide polymorphism; Genotype; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004157075,0.0008268877,0.000941922,0.003710368,0.0007825777,0.002179563,0.0007489723,0.0005332571,0.003687159],"category_scores_gemma":[0.01607298,0.0002390291,0.001162229,0.004320186,0.000674365,0.0009818283,0.001968608,0.0007776153,0.001224353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005175099,"about_ca_system_score_gemma":0.0006864079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001351908,"about_ca_topic_score_gemma":0.002297166,"domain_scores_codex":[0.9962773,0.001446309,0.0004392529,0.0009878153,0.0006750589,0.0001743548],"domain_scores_gemma":[0.9911647,0.005213719,0.001378694,0.001056479,0.0009399142,0.0002465135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002658165,0.000331537,0.4909377,0.002709266,0.001956381,0.002145363,0.001409622,0.03094844,0.2484732,0.01274015,0.003916783,0.2017733],"study_design_scores_gemma":[0.0001883171,0.0007920351,0.5162864,0.0002978372,0.001296794,0.003772879,0.001520717,0.2007881,0.1538144,0.05597999,0.06488024,0.0003822686],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.64025,0.002390261,0.3355435,0.0006671703,0.0002161476,0.0001716628,0.01100729,0.002725973,0.007027992],"genre_scores_gemma":[0.8126484,0.0003714394,0.1798541,0.0001186078,0.00005288325,0.0001236979,0.005596313,0.0003323416,0.0009022813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004157075,"threshold_uncertainty_score":0.02198499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093917129537697,"score_gpt":0.296596566580715,"score_spread":0.2756573952853381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}