{"id":"W4388684162","doi":"10.3389/fnagi.2023.1277731","title":"X chromosome-wide association study of quantitative biomarkers from the Alzheimer’s Disease Neuroimaging Initiative study","year":2023,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Science and Technology Planning Project of Guangdong Province; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Basic and Applied Basic Research Foundation of Guangdong Province; University of Southern California; Pfizer; BioClinica; Biogen; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association","keywords":"Single-nucleotide polymorphism; Autosome; Disease; Genetic association; Genetics; Biology; Dementia; Neuroimaging; Chromosome; Gene; Medicine; Genotype; Pathology; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00168247,0.0007043915,0.0007848679,0.001125647,0.0008055392,0.0009296768,0.0006531847,0.0006727759,0.003786731],"category_scores_gemma":[0.004442954,0.0002326192,0.0008154744,0.002941933,0.000281717,0.0004409199,0.0007506197,0.0008674742,0.0004658765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003002475,"about_ca_system_score_gemma":0.0003846701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004874957,"about_ca_topic_score_gemma":0.003985117,"domain_scores_codex":[0.9973021,0.0007814199,0.0003326467,0.001073403,0.0003715405,0.0001389142],"domain_scores_gemma":[0.9979036,0.000476984,0.0008258835,0.0002355268,0.0003556273,0.0002024594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001056951,0.00005156836,0.9823153,0.0002803209,0.002370616,0.0002712926,0.000145001,0.0001963399,0.0008924156,0.000439826,0.003645334,0.0083351],"study_design_scores_gemma":[0.0001469045,0.0001255292,0.9930131,0.0000610199,0.0009213238,0.000434666,0.0000643999,0.000203638,0.0002377428,0.0004959116,0.004280137,0.00001567651],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9367169,0.01239316,0.003707409,0.00129393,0.000258014,0.0002646197,0.03782897,0.0001029387,0.007433963],"genre_scores_gemma":[0.9726549,0.001743201,0.002584692,0.000458932,0.0002032783,0.000517366,0.02004149,0.00002669879,0.001769551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004874957,"threshold_uncertainty_score":0.01266789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04926098292994525,"score_gpt":0.3195474170308482,"score_spread":0.2702864341009029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}