{"id":"W4388688059","doi":"10.1056/nejmoa2304430","title":"Two Phase 3 Trials of Gantenerumab in Early Alzheimer’s Disease","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":280,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Institute on Aging; Chugai Pharmaceutical; National Institute of General Medical Sciences; Genentech; F. Hoffmann-La Roche","keywords":"Disease; Alzheimer's disease; Clinical trial; Psychology; Medicine; Neuroscience; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004131658,0.001900625,0.003141803,0.0006385916,0.0005574872,0.001110658,0.001384201,0.002638121,0.005045579],"category_scores_gemma":[0.003479381,0.0007444385,0.002392656,0.0004463388,0.0009028724,0.0011054,0.0006367572,0.003677429,0.0008910214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009864818,"about_ca_system_score_gemma":0.001349862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006533838,"about_ca_topic_score_gemma":0.001672937,"domain_scores_codex":[0.9982877,0.001010112,0.0001057213,0.0002037398,0.0001547131,0.0002380286],"domain_scores_gemma":[0.9977131,0.0005489643,0.0005462437,0.0002022355,0.0002650316,0.0007244446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9395071,0.01746967,0.001173989,0.0008201905,0.00091953,0.00006586432,0.0001593761,0.0003972294,0.005694139,0.0001898587,0.002109116,0.031494],"study_design_scores_gemma":[0.883756,0.1114872,0.002189234,0.0000544581,0.0001997787,0.00004970596,0.00002336805,0.0001634698,0.0004421833,0.0001755307,0.001444726,0.00001441611],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637149,0.008798866,0.001659896,0.001692841,0.0007439078,0.01749846,0.002217971,0.0002120634,0.003461085],"genre_scores_gemma":[0.9377568,0.004979759,0.005188293,0.00387061,0.0008532148,0.03953418,0.003335065,0.00005635903,0.004425732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005045579,"threshold_uncertainty_score":0.02185059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1221990151143985,"score_gpt":0.4295541599013922,"score_spread":0.3073551447869937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}