{"id":"W4388688059","doi":"10.1056/nejmoa2304430","title":"Two Phase 3 Trials of Gantenerumab in Early Alzheimer’s Disease","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":280,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"National Institute on Aging; Chugai Pharmaceutical; National Institute of General Medical Sciences; Genentech; F. Hoffmann-La Roche","keywords":"Disease; Alzheimer's disease; Clinical trial; Psychology; Medicine; Neuroscience; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002897751,0.0001920391,0.001209279,0.0008185937,0.0000294531,0.000006745006,0.000140945,0.00004287164,0.0004026257],"category_scores_gemma":[0.002304477,0.0001143992,0.0002434602,0.0006520964,0.0001458295,0.0001188187,0.00002871794,0.0003077593,0.00002706658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004234737,"about_ca_system_score_gemma":0.0007839889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002610563,"about_ca_topic_score_gemma":0.00001596503,"domain_scores_codex":[0.9968094,0.0003403742,0.001275934,0.0001665328,0.001047676,0.0003600509],"domain_scores_gemma":[0.9970308,0.0006799506,0.0005211264,0.0002494517,0.0002711334,0.001247532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.08518478,0.003708344,0.3064617,0.0002840357,0.02100434,0.04198693,0.002741254,0.00007863012,0.004589734,0.0004007831,0.03348833,0.5000712],"study_design_scores_gemma":[0.7329527,0.0110234,0.2314709,0.003775426,0.008367664,0.0006207261,0.0005478993,0.000334695,0.002081922,0.00341691,0.005117149,0.0002906703],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623495,0.02863926,0.00002546369,0.007761708,0.0003309299,0.0004139788,0.00003537799,0.00001928607,0.0004244446],"genre_scores_gemma":[0.9951914,0.002308714,0.00009194172,0.0001290366,0.002121966,0.000004385831,0.00004410594,0.00002487548,0.00008355125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6477679,"threshold_uncertainty_score":0.4665062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1221990151143985,"score_gpt":0.4295541599013922,"score_spread":0.3073551447869937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}