{"id":"W4388688425","doi":"10.15252/emmm.202317719","title":"LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition","year":2023,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université Laval","funders":"Fonds de recherche du Québec; Institute of Cancer Research; Institut National Du Cancer; Fonds de Recherche du Québec - Santé; Fondation de France; Ligue Contre le Cancer; University of Hong Kong; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; CNIB","keywords":"Melanoma; Chemistry; Cancer research; Apoptosis; Molecular biology; Cell biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002649616,0.0001762762,0.000349254,0.0002095847,0.0001119932,0.000008623865,0.00001733741,0.0001265025,0.00001739076],"category_scores_gemma":[0.0002106852,0.0001416257,0.00003041682,0.0002807986,0.000181728,0.00005906801,0.00005208174,0.000140081,0.00005051277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000405206,"about_ca_system_score_gemma":0.00003939123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002550379,"about_ca_topic_score_gemma":0.00001708593,"domain_scores_codex":[0.9988751,0.00009227431,0.0001872318,0.0003632186,0.0002488519,0.0002332776],"domain_scores_gemma":[0.9993964,0.00005131429,0.00004284115,0.000184437,0.00007230504,0.0002526393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009695698,0.0004184698,0.2124104,0.0003798551,0.0006332639,0.01709961,0.005685406,0.00001368037,0.7168022,0.002813025,0.002799269,0.0399753],"study_design_scores_gemma":[0.0120618,0.00493872,0.9012836,0.0006210119,0.000812392,0.002161515,0.0008259165,0.0008209045,0.0706716,0.00126876,0.004113691,0.000420043],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798087,0.0003321249,0.0004541518,0.01714091,0.000122419,0.0006700722,0.000005724045,0.0001067701,0.001359069],"genre_scores_gemma":[0.9961792,0.00008701183,0.0003501862,0.002672177,0.0001663537,0.00003963821,0.0001506703,0.0000230833,0.0003317198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6888733,"threshold_uncertainty_score":0.577533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157056426360049,"score_gpt":0.2837675800488108,"score_spread":0.2721970157852103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}