{"id":"W4388688425","doi":"10.15252/emmm.202317719","title":"LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition","year":2023,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université Laval","funders":"Fonds de recherche du Québec; Institute of Cancer Research; Institut National Du Cancer; Fonds de Recherche du Québec - Santé; Fondation de France; Ligue Contre le Cancer; University of Hong Kong; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; CNIB","keywords":"Melanoma; Chemistry; Cancer research; Apoptosis; Molecular biology; Cell biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001088549,0.0002608747,0.0002329112,0.0002203073,0.0001822227,0.0002928807,0.0001278408,0.0002390909,0.002101574],"category_scores_gemma":[0.0000966637,0.0001736431,0.0001998714,0.0001533792,0.0002295032,0.000109131,0.0002027521,0.0004836616,0.0004073082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003341247,"about_ca_system_score_gemma":0.0001890284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008097335,"about_ca_topic_score_gemma":0.001648185,"domain_scores_codex":[0.9998382,0.00002713008,0.00001740362,0.00003433009,0.00004831766,0.00003460426],"domain_scores_gemma":[0.9998728,0.00001811377,0.00004506805,0.00001633842,0.000008507991,0.00003925263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006836407,0.00002040181,0.0002370472,0.00001226562,0.000003212774,0.00005351663,0.000006336668,0.00003655027,0.9991295,0.00004548195,0.00004686068,0.0003405135],"study_design_scores_gemma":[0.00002605851,0.0002500838,0.009787563,0.000005605445,0.00001465893,0.0005782631,0.00004595147,0.002457116,0.9844514,0.00006158623,0.002315142,0.000006498772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957228,0.0004747646,0.001571647,0.0001292043,0.00002778747,0.00002232422,0.0005739991,0.0001359724,0.001341489],"genre_scores_gemma":[0.9966538,0.0001554317,0.0008831596,0.0000386944,0.000004153119,0.0000234556,0.0002575523,0.00002631266,0.001957403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002101574,"threshold_uncertainty_score":0.007030427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157056426360049,"score_gpt":0.2837675800488108,"score_spread":0.2721970157852103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}