{"id":"W4388688765","doi":"10.21203/rs.3.rs-3568544/v1","title":"Hyper-physiologic mechanical cues, as an osteoarthritis disease relevant environmental perturbation, cause a critical shift in set-points of methylation at transcriptionally active CpG sites in neo-cartilage organoids","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"ZonMw; National Institutes of Health; Medical Delta; Universiteit Leiden; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dutch Arthritis Society; Arthritis Society; Shriners Hospitals for Children","keywords":"CpG site; DNA methylation; Osteoarthritis; Cartilage; Organoid; Methylation; Biology; Medicine; Cell biology; Pathology; Gene; Anatomy; Genetics; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007568121,0.0001881923,0.0001754368,0.0002122048,0.0001463493,0.0002672152,0.000180553,0.0002797492,0.007694584],"category_scores_gemma":[0.0001203223,0.0001205629,0.0002322012,0.0001431033,0.0001913603,0.0001648855,0.0002486148,0.0005290915,0.001463516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003140868,"about_ca_system_score_gemma":0.0001752214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001020726,"about_ca_topic_score_gemma":0.001781063,"domain_scores_codex":[0.99985,0.00001354118,0.00001353315,0.00005250074,0.00003906133,0.00003124596],"domain_scores_gemma":[0.9999263,0.00001299939,0.00001922933,0.00001072856,0.00001021026,0.00002052481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008947867,0.00001216405,0.0002728585,0.00004773038,0.000003943976,0.00003197713,0.00001289922,0.00005247239,0.9978862,0.00007869139,0.0002045927,0.001306943],"study_design_scores_gemma":[0.00001704173,0.0002149569,0.02070589,0.00001842355,0.00001744476,0.0001909381,0.0000833192,0.000710093,0.9700058,0.0001212828,0.0079039,0.0000109022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717302,0.004802455,0.007852338,0.0005436601,0.0003886931,0.00006140512,0.006378809,0.0003911848,0.007851249],"genre_scores_gemma":[0.9851848,0.001101399,0.002379142,0.0003074244,0.0000314974,0.00007605863,0.003195278,0.0000732929,0.00765119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007694584,"threshold_uncertainty_score":0.02574092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07036259765022689,"score_gpt":0.3711451554312231,"score_spread":0.3007825577809962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}